Benoît Thibault

This study shows that p53 mutations enhance cancer cell survival and growth under mechanical compression, suggesting p53 status as a biomarker for tumor adaptation to stress.

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

The paper shows that mechanical compression increases PI3K signaling in breast and pancreatic cancer cells, enhancing resistance to PI3K inhibitors and affecting autophagy.

This study shows that meat-enriched diets and inflammation promote pancreatic cell plasticity via PI3Kα, which limits tissue regeneration and increases cancer risk.