Ting Zhang

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.