Hind Medyouf

This study identifies Spp1⁺ macrophages as key hubs coordinating fibrotic remodeling in myeloproliferative neoplasms using NicheSphere, a novel computational method for cell communication analysis.

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.

This study shows that blocking ATP-to-adenosine enzymes and combining with radiotherapy improves anti-cancer immunity in brain metastases by altering immune cell populations and tumor inflammation.