Allison Ballandras-Colas

This paper identifies an intracellular nanobody that inhibits influenza A virus RNA-polymerase by blocking PA-PB1 dimer nuclear import, showing potential for antiviral development.

The paper presents the 3.8 Å cryo-EM structure of the VACV DNA polymerase holoenzyme and shows its structural similarity to MPXV, with transient E9-D4 interactions and conformational flexibility.