Author
Nanyang Technological UniversityORCID 0000-0003-4843-9605Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Rae Chua, Stephen Wearne, Shirley Suet Lee Ding…·Franklin L. Zhong
This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.
Pritisha Rozario, Ying Shiang Lim, Shirley Suet Lee Ding…·Franklin L. Zhong
This study investigates NLRP3 inflammasome activation in human keratinocytes, showing it is induced by IFN-gamma but not LPS, and that specific activators like Hla target NLRP3 while nigericin activates both NLRP1 and NLRP3.
Pritisha Rozario, Miriam Pinilla, Anna Constance Vind…·Franklin Zhong
This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.