Cancer BiologyJournal of Biological ChemistryPeer-reviewed
Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant negative manner
Paige Blinkiewicz, Nicole C Hoenes, Muhammad Zubair Afzal…·Prerna Malaney
This study shows that colorectal cancer-associated PCBP1 mutations destabilize the protein and act as dominant-negative variants, inactivating the tumor suppressor function.
DOI 10.1016/j.jbc.2026.113376