Kaitlyn A. Sun

This study benchmarks donor-specific assemblies for improved detection of somatic structural variants in a melanoma cell line, finding they identify more variants, especially in repeat-rich regions.

The paper identifies a segmental duplication that drives position effect expression of TBC1D3 in the human brain, explaining its high structural heterozygosity.

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

The paper shows HIF-1α regulates glycolytic shifts and mitochondrial function differently in bone marrow-derived macrophages compared to tissue-resident alveolar macrophages.