Cell BiologybioRxivPreprint
Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations
Tong Xu, Vera Janssen, Nathalie R. Reinhard…·Stephan Huveneers
This study identifies a calcineurin-NFAT-DSCR1.4 signaling axis driven by Gq-R183Q mutation in endothelial cells, showing its role in capillary malformations and potential as a therapeutic target.
DOI 10.1101/2025.06.07.658432