Author

Sofia Malik

Washington University in St. LouisORCID 0009-0008-3756-9686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:organoid / primary culture· 1 Approach:statistical model· 1

Frequent Co-Authors

Faiza BatooliD· 2 shared Gareth ChapmaniD· 2 shared Haley JetteriD· 2 shared Julianna J. DetermaniD· 2 shared Kristen L. KrolliD· 2 shared Sydney R. CrumpiD· 2 shared Caleb Valentine· 1 shared Harrison W. GabeliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersDevelopmental Biology

Faiza BatoolORCID

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintFeb 17, 2026

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation

Julianna J. Determan, Gareth Chapman, Sydney R. Crump…·Kristen L. Kroll

This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates gene expression, with distinct pathogenic mechanisms in deficiency and mutation models.

1 citation

humanorganoid / primary culture

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 24, 2025

Tatton-Brown-Rahman-Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

Gareth Chapman, Julianna J. Determan, John R. Edwards…·Kristen L. Kroll

This study shows that DNMT3A mutations in TBRS disrupt cortical interneuron differentiation, leading to neuronal network dysfunction and contributing to intellectual disability and autism.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky