Author

Léa El Hajjar

Centre National de la Recherche ScientifiqueORCID 0009-0008-6476-0742Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Cláudio M. GomesiD· 1 shared Clément DanisiD· 1 shared Elian DupréiD· 1 shared François‐Xavier CantrelleiD· 1 shared Isabelle LandrieuiD· 1 shared Jean‐Christophe RainiD· 1 shared Justine MortelecqueiD· 1 shared Luc BuéeiD· 1 shared

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2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Cláudio M. GomesORCID

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1 paper

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedMar 12, 2024

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

Justine Mortelecque, Orgeta Zejneli, Séverine Bégard…·Elian Dupré

The paper optimizes VHH antibodies targeting Tau's PHF6 peptide through mutagenesis and screening, showing improved binding and aggregation inhibition, but also highlighting the importance of stability beyond affinity.

10 citations

protein structureexperimental assay

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