Cancer BiologyCancer CellPeer-reviewed
Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion
Rei Kudo, Anton Mikhailovich Safonov, Catherine Jones…·Sarat Chandarlapaty
The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.
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