Impact of proteogenomic evidence on clinical success
Mohd Anisul KarimiD, Abhay Hukku, Bruno ArianoiD, Emily Rose HolzingeriD, Yakov A. TsepiloviD, James D. HayhurstiD, Annalisa BunielloiD, Ellen M. McDonaghiD, Stephane E. CasteliD, Matthew R. NelsoniD, Joseph MaranvilleiD, Laura M. Yerges-ArmstrongiD, Maya GhoussainiiD
Abstract
We assessed the impact of plasma protein quantitative trait loci (pQTL) on genetically supported therapeutic hypotheses. We show that pQTL-supported target-indication pairs were 4.4 times more likely to advance from Phase I to launch, compared to a 2.6-fold increase observed with other human genetic evidence. Moreover, pQTL-based enrichment was prominent in druggable protein families which had limited enrichment from other genetic evidence sources.
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