Motivational control is implemented by a cingulo-prefrontal pathway

Clémence Gandaux; Jérôme Sallet; Céline Amiez; Delphine Autran-Clavagnier; Valentine Morel-Latour; Clément Goussi-Denjean; Vincent Fontanier; Pierre Misery; Camille Lamy; Franck Lamberton; Marina Lavigne; Eric J. Kremer; Charles R. E. Wilson; Emmanuel Procyk

doi:10.1101/2025.02.11.637635

NeurosciencebioRxivFeb 11, 2025

Preprint

Motivational control is implemented by a cingulo-prefrontal pathway

Clémence Gandaux iD, Jérôme Sallet iD, Céline Amiez iD, Delphine Autran-Clavagnier, Valentine Morel-Latour iD, Clément Goussi-Denjean iD, Vincent Fontanier iD, Pierre Misery, Camille Lamy iD, Franck Lamberton iD, Marina Lavigne iD, Eric J. Kremer iD, Charles R. E. Wilson iD, Emmanuel Procyk iD

Abstract

The neuronal connections between the midcingulate cortex (MCC) and the dorsolateral prefrontal cortex (dlPFC) are associated with multiple cognitive functions, including rapid and long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led to increased engagement in a foraging task, but did not alter their trial-to-trial adaptive strategy. We conclude that a critical role for MCC-dlPFC pathway is in the temporally extended control of behaviour rather than in rapid adaptation.

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