Opposing transcriptomic gradients explain orthogonal maps in human visual areas

Opposing transcriptomic gradients explain the large-scale organization of cortex. Here, we show that opposing transcriptomic gradients also explain the fine-scale organization of orthogonal maps in human visual areas. We propose a model relating transcriptomics, cell density, and function, which predicts that specific cortical locations within these visual maps are microanatomically distinct and differentially susceptible to genetic mutations. We conclude with histological and translational data that support both predictions.