CORe Designer: a CRISPR design tool for proteome engineering
Akashaditya DasiD, Janessa GrechiD, Selina Hung, Jiali WuiD, Celeste Callafe, Annabel Corrie, Kevin Yeung, Ione GoodwiniD, Daisy Yu, Sarah HassaniD, Kimberley Reid, Marko StorchiD, Matthew A. ChildiD
Abstract
Precision proteome engineering requires tools that leverage CRISPR technologies, yet most current design platforms remain gene-centric. To bridge this gap, we introduce CORe Designer. Featuring an intuitive graphical user interface, CORe Designer enables researchers to design guide RNAs and homology-directed repair templates in a protein-centric manner. By automating these workflows, CORe Designer enables the design of targeted mutagenesis experiments for precision proteome engineering to be completed in minutes.
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