Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

Frances M. K. Williams; Maxim B. Freidin; Massimo Mangino; Simon Couvreur; Alessia Visconti; Ruth C. E. Bowyer; Caroline Ivanne Le Roy; Mario Falchi; Olatz Mompeó; Carole H. Sudre; Richard Davies; Christopher J. Hammond; Cristina Menni; Claire Joanne Steves; Tim D. Spector

doi:10.1017/thg.2020.85

Genetic & Genomic MedicineTwin Research and Human GeneticsDec 1, 2020

Peer-reviewed journal article

Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

Frances M. K. Williams iD, Maxim B. Freidin iD, Massimo Mangino iD, Simon Couvreur iD, Alessia Visconti iD, Ruth C. E. Bowyer iD, Caroline Ivanne Le Roy iD, Mario Falchi iD, Olatz Mompeó iD, Carole H. Sudre iD, Richard Davies iD, Christopher J. Hammond iD, Cristina Menni iD, Claire Joanne Steves iD, Tim D. Spector iD

Abstract

Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.

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