Emergence of Candida auris in Minas Gerais, Brazil: Genomic Surveillance to inform Rapid Public Health Responses

Luíz Marcelo Ribeiro Tomé; Dhian Renato Almeida Camargo; Rafael Wesley Bastos; Sara Cândida Ferreira dos Santos; Natália Rocha Guimarães; Sílvia Helena Sousa Pietra Pedroso; Paulo Eduardo de Souza da Silva; Aristóteles Goés‐Neto; Lida Jouca de Assis Figueredo; Gilberto de Castro; Ana Maria Ribeiro Nunes Rodrigues; Flavia Ribeiro Soares Cruzeiro; Nádia Aparecida Campos Dutra; Josiane Barbosa Piedade Moura; Glauco de Carvalho Pereira; Carmem Dolores Faria; Marta Giovanetti; Felipe Campos de Melo Iani; Luiz Carlos Júnior Alcantara; Talita Adelino

doi:10.1101/2024.12.13.627932

GenomicsbioRxivDec 13, 2024

Preprint

Emergence of Candida auris in Minas Gerais, Brazil: Genomic Surveillance to inform Rapid Public Health Responses

Luíz Marcelo Ribeiro Tomé iD, Dhian Renato Almeida Camargo, Rafael Wesley Bastos iD, Sara Cândida Ferreira dos Santos iD, Natália Rocha Guimarães iD, Sílvia Helena Sousa Pietra Pedroso iD, Paulo Eduardo de Souza da Silva iD, Aristóteles Goés‐Neto iD, Lida Jouca de Assis Figueredo iD, Gilberto de Castro iD, Ana Maria Ribeiro Nunes Rodrigues, Flavia Ribeiro Soares Cruzeiro iD, Nádia Aparecida Campos Dutra, Josiane Barbosa Piedade Moura, Glauco de Carvalho Pereira, Carmem Dolores Faria, Marta Giovanetti iD, Felipe Campos de Melo Iani iD, Luiz Carlos Júnior Alcantara, Talita Adelino iD

Abstract

Candida auris poses a significant global health threat due to its multidrug-resistance and outbreak potential. In this study, we report its emergence in Minas Gerais, Brazil, supported by genomic surveillance that identified Clade-IV isolates, suggested a potential introduction from Colombia, and detected a missense mutation associated with azole resistance.

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