Autoregulation of three yeast ribosomal protein genes by splicing inhibition
David M. Granas, Anirudh Kesanapally, Michael A. WhiteiD, Gary D. StormoiD
Abstract
Yeast ribosomal protein genes RPL18B, RPL28 and RPS22B are autoregulated by inhibition of splicing. This is demonstrated by inserting their introns into a chromosomal copy of GFP and observing repression upon induction of the cognate protein. In RPL18B and RPS22B, a predicted conserved secondary structure within the intron is required for regulation, while in RPL28 it is not.
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