Phage genome architecture and GC content: Structural genes and where to find them
Abstract
Bacteriophages, the ubiquitous bacterial viruses, are the most abundant biological entities on Earth. However, information regarding the impact of environmental factors on the genetic makeup of phages is scarce. Based on the analysis of genomes of 45 phage isolates from different ecosystems we demonstrate a significant (p 50 kb, but not for genomes < 50 kb (p = 0.556). We therefore propose a relationship of structural genes and GC content, a property that may influence the adaptation and evolution of phages in various environmental niches.
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