Flexible multivariate linear mixed models for structured multiple traits
Hyeonju KimiD, Gregory FarageiD, John T. LovelliD, John K. Mckay, Thomas E. Juenger, Śaunak SeniD
Abstract
Many genetic studies collect structured multivariate traits containing rich information across traits. We present a flexible multivariate linear mixed model for quantitative trait loci mapping (FlxQTL) for multiple correlated traits that adjusts for genetic relatedness and that models information on multiple environments or multiple timepoints using trait covariates. FlxQTL handles genetic mapping of multivariate traits faster with greater flexibility compared to previous implementations.
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