Topographic reference modelling of white matter hyperintensities across the adult lifespan
Mohamad J. Alshikho, Jeffrey D. Pyne, Natalie C. Edwards, Christiane Hale, Dejania Cotton Samuel, Clarissa D. Morales, Natalie Morel, Rafael Vignoli Lippert, Derek B Archer, Michael L. Cuccaro, Arthur W. Toga, Andrew J. Saykin, Shannon L. Risacher, Michael E. Belloy, Walter Kukull, , Adam M. Brickman
This paper introduces vTRM, a framework to characterize WMH spatial patterns across age and sex, revealing distinct associations with aging, vascular, and neurodegenerative processes.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience