Duo Peng

OocystMeter automates oocyst counting and sizing in mosquito midguts, revealing clustered spatial patterns in malaria infections.

This study shows that JNK signaling in Anopheles gambiae reduces reproductive investment and survival after Plasmodium infection by suppressing ecdysteroid production.

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

RNAquarium integrates zebrafish and metatranscriptomic data to identify viral drivers of transcriptomic states and support foundation-model training.

This study uses single-cell RNA sequencing to map Plasmodium transitions and interactions in Anopheles mosquitoes, identifying key molecular processes and potential targets for transmission-blocking strategies.

This study uses targeted CRISPR screens to identify essential genes for Cryptosporidium survival, finding Cp23 is critical for gliding motility and reinfection.

This study uses CRISPR screening and single-cell RNA sequencing to analyze host factors and transcriptional changes in RSV-infected and bystander cells, revealing distinct gene expression patterns and host dependencies.

This paper develops a CRISPR knockout screening method using viral replicons to identify host factors essential for viral replication, successfully identifying known and novel genes for dengue, chikungunya, and Ebola viruses.

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

protoSpaceJAM automates and optimizes CRISPR/Cas9 gRNA and HDR donor design, improving knock-in efficiency through recoding mutations and customizable parameters.

MaGplotR aggregates and visualizes multiple CRISPR screen datasets to identify common hits and generate publication-quality plots.