Schizophrenia research and treatment

The paper identifies genetic markers linked to clozapine-induced metabolic dysfunction using Mendelian randomization and colocalization analyses, suggesting potential biomarkers for precision medicine.

The paper maps protein-protein interactions of schizophrenia risk factors in rodent brains, revealing an interconnected disease network and showing how PCP perturbations alter these interactions.

This study identifies reduced beta-band neural modulation as a shared mechanism linking perceptual, motor, and language impairments in schizophrenia.

The paper identifies dysregulation of cholesterol metabolism as a shared molecular consequence of schizophrenia risk mutations in zebrafish models.

This study identifies individual-level brain structure deviations and their gene expression signatures in early-onset schizophrenia, revealing two distinct transcriptomic subtypes associated with different neurodevelopmental processes.

This study identifies microstructural abnormalities in the forceps minor white matter tract in schizophrenia using DTI, suggesting it as a potential biomarker and linking it to social behavior dysfunction.

This paper proposes a neural model linking NMDA hypofunction and dopaminergic hyperfunction to schizophrenia spectrum disorders through prediction error pathways, explaining clinical diversity as a bias-volatility spectrum.

The paper identifies higher-order thalamus as a critical node in schizophrenia pathophysiology, showing that restoring its activity can normalize connected brain regions.

This study investigates time perception in schizophrenia by examining how individuals with schizophrenia and controls perform in detecting millisecond-level stimulus asynchronies, finding a specific difficulty in schizophrenia patients.

This study links sulcal widening in schizophrenia to network hubs and genes involved in synaptic signaling and energy metabolism.

This study examines beta-burst dynamics in schizophrenia patients and controls, finding dissociable anterior and posterior abnormalities linked to speech markers of thought disorder.

This study conducts a GWAS and cross-ethnic meta-analysis of schizophrenia phenotypes in Hong Kong Chinese and European populations, identifying genetic variants and building predictive models for clinical outcomes.

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

The paper integrates gene expression analysis with computational modeling to show region-specific energy metabolism dysregulation in schizophrenia, identifying key genes and metabolite changes in ACC and DLPFC.

This study investigates how 5-HT7 receptors modulate hippocampal-prefrontal circuits in schizophrenia models, finding that their blockade improves cognitive and emotional symptoms.

This study identifies sex-specific molecular and functional changes in a schizophrenia model, revealing convergent inhibitory deficits through divergent pathways.

This study shows that increased inter-trial latency variability and reduced neural responses both contribute to diminished visual EEG N1 amplitudes in schizophrenia.

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

This paper investigates the role of Reelin in schizophrenia by analyzing a mouse model with exonic Reln deletion, finding deficits in excitatory and inhibitory neurons and suggesting therapeutic potential for Reelin replacement.

This study examines the effects of Grin2a and Akap11 mutations on striatal dopamine dynamics and behavior in mice, revealing distinct impacts on locomotion and neural activity.

This study identifies FOXP1-regulated genes across developmental stages and shows their enrichment for schizophrenia heritability, particularly in early childhood and adolescence.

The paper performs transcriptomic analysis of the human habenula and identifies molecular changes associated with schizophrenia risk and illness state.

The paper links brain entropy to molecular and cellular architecture in psychosis by analyzing differences in neurotransmitter systems and mitochondrial markers between healthy controls and individuals with schizophrenia or bipolar disorder.

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

This study investigates altered sense of agency in first-episode schizophrenia patients using neuroimaging, finding consistent DMN hypo-activation across two independent cohorts.

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

This paper reviews sex differences in latent inhibition, finding inconclusive evidence but suggesting sex differences in hippocampal processing and vulnerability to perturbations.

The paper identifies CeA-PnC glutamatergic synapses as a therapeutic target for reversing PPI deficits in schizophrenia models using photo-tagging and PRODH-deficient mice.

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

This study uses fMRI to examine neural correlates of schizotypal traits during discourse planning and production, finding trait-specific activation patterns in brain regions associated with theory of mind and social cognition.