Substance Abuse Treatment and Outcomes

The paper identifies distinct neural circuits and biotypes in alcohol drinkers based on appetitive and aversive cue reactivity using fMRI data.

This study compares stress and affect levels in middle-aged and younger adults during alcohol consumption and abstinence, finding age-related differences in stress reduction and affect.

This study examines how cognitive behavioral therapy (CBT) for alcohol use disorder (AUD) affects brain activity in the dorsolateral prefrontal cortex (DLPFC) and reduces heavy drinking and craving.

This study identifies shared and unique proteomic pathways affected by alcohol, opioid, and combined substance misuse disorders using postmortem brain samples.

The paper investigates if healthy alcohol consumers rate alcohol desire and craving similarly using related descriptors, finding consistent differences in ratings during drinking, abstinence, and alcohol cue exposure.

This study examines how binge drinking affects gray matter volume decline in adolescents over time, finding stronger effects in younger individuals and suggesting potential for recovery with temporally proximal drinking.

This study identifies genetic variants associated with AUD treatment outcomes using pharmacogenomic analyses of naltrexone and acamprosate responses.

This study uses a data-driven method to show that alcohol use in adolescents affects cortical thinning differently across age groups.

The paper examines how negative urgency relates to hazardous alcohol use through cognitive control and reinforcement processing mechanisms using EEG data.

This study uses fMRI to show gender differences in brain activation patterns in response to alcohol cues in abstinent individuals with alcohol use disorders.

The paper uses causal discovery analysis to build an integrated multimodal model of AUD, identifying key causal factors from brain function to social and affective factors.

This study shows that adolescent binge ethanol exposure leads to sex-dependent changes in ethanol consumption and motor activity in adult C57BL/6J mice, with males showing increased consumption and females showing decreased consumption and reduced center zone activity.

This study conducts a meta-analysis of VBM studies to identify gray and white matter morphology changes in substance use disorders, finding both convergent and divergent effects based on substance type and consumption severity.

The paper identifies a reproducible structural brain pattern linked to age at first full drink before 21, using JIVE analysis on neuroimaging data from two datasets.

The paper examines how alcohol use disorder, gender, age, and abstinence affect hippocampal subfield volumes in abstinent individuals.

This study uses fMRI to compare brain responses to alcohol and non-alcohol-related cues in individuals with severe AUD and healthy controls, finding differences in BOLD responses to drinking-related images.

This study examines how binge drinking affects globus pallidus connectivity and its relationship with impulsivity and drinking behaviors in humans.

The paper uses ensemble machine learning to predict future drinking in young adults by combining MRI, psychometric, and behavioral data, finding that specific neuroimaging and non-neuroimaging factors are strong predictors.

The paper develops and validates a database of pictorial cues for methamphetamine and opioids, showing drug images elicit higher arousal and lower valence than neutral images.

The paper examines neurocognitive and psychiatric traits in siblings with opiate or stimulant dependence to identify common and substance-specific endophenotypes.

The paper identifies smaller brain volumes in the right dorsolateral prefrontal cortex and insula as predispositional risk factors for alcohol use, supported by genetic and longitudinal evidence.

The paper examines brain and behavioral responses to social alcohol cues and their link to drinking in a social setting, finding no significant association.

The paper examines gender differences in brain responsivity to emotional stimuli in individuals with and without alcoholism, finding reduced activation in alcoholic men and increased activation in alcoholic women in specific brain regions.

The paper examines markers of allostatic load in individuals with comorbid cocaine and alcohol use disorders, finding associations between substance use duration and white matter integrity.

This study evaluates how naltrexone affects ethanol drinking in male and female rats during different stages of abstinence, finding sex-specific and time-dependent effects.

The paper identifies two trajectories of alcohol use initiation in adolescents and links early initiation to increased risk of AUD, stress, and amygdala reactivity.

This study shows that inhibiting glyoxalase 1 with pBBG reduces alcohol self-administration in both dependent and nondependent rats, with greater effect in dependent animals.