Neurotransmitter Receptor Influence on Behavior

This study examines how chronic alcohol drinking affects sex-specific affective behavior and medial prefrontal cortex activity in CRF1:Cre:Tdtomato transgenic rats, finding that alcohol intake correlates with anxiety and depressive-like behaviors and CRF1 neuron activity.

This study shows that Mfn2 in NAc D2-MSNs regulates social dominance and neuronal function, while D1-MSNs show transient effects on competitiveness.

This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.

This study identifies a human brain signature of pleasure using fMRI, showing it is sensitive to pleasant tastes and humor, and linked to opioid receptor activity.

The paper models cognitive conflict in addiction by proposing an algorithmic framework that explains how drug-seeking persists despite negative outcomes.

The paper identifies neurobehavioral markers in rats that predict future compulsive cocaine seeking behavior through pre-existing functional and structural brain changes.

The paper investigates how VP GABA neurons encode reward-seeking behavior through calcium activity in response to cues and reward expectation in rats.

This study identifies transcriptional changes in the brain reward circuit across heroin exposure and seeking behaviors in mice, revealing molecular mechanisms and potential therapeutic targets for opioid use disorder.

The paper investigates the neural circuits and cell-specific contributions to risk-taking behavior in male and female rats during decision-making tasks involving punishment.

This study shows that cholinergic interneurons in the nucleus accumbens drive dopamine release, influencing motivated behavior in rats.

This study uses machine learning to distinguish dopamine modulation features between neuroanatomical regions and stimulation strengths in adult animals, finding unique predictive features not detectable by conventional analysis.

This study examines sex-specific effects of intermittent cocaine self-administration on addiction-like behaviors in rats, finding increased motivation in females and compulsive behavior in males.

This study shows that activating TAAR1 reduces alcohol consumption in mice, suggesting it as a potential target for treating alcohol abuse.

This study shows that increasing dopamine D2 receptors in nucleus accumbens cholinergic interneurons increases impulsive choice in mice, while reducing them decreases impulsive choice.

The paper develops a predictive model of cocaine relapse using dopamine release patterns and sex, showing that these factors predict relapse and extinction resistance.

This study shows that alcohol-dependent rats show increased habitual behavior towards a sweet reward in two tasks, and DMS inactivation in non-dependent rats also increases habitual behavior.

This study examines dopamine signaling in the dorsal bed nucleus of the stria terminalis during Pavlovian learning and reward violations, revealing strategy-dependent patterns of dopamine responses.

The paper compares risky decision-making and impulsivity between two Lewis rat substrains, finding significant phenotypic differences linked to genetic variants.

This study identifies distinct roles of VTA and SNc dopamine neurons in instrumental learning through behavioral tasks and optogenetic manipulations, showing they support different reinforcement mechanisms.

This study compares Pavlovian and operant conditioning in rats to show that operant action anticipation induces sustained dopamine release in the nucleus accumbens, distinct from reward prediction error signals.

The paper identifies a locus coeruleus-hippocampal dopamine pathway involved in operant reinforcement by showing D1+ dentate gyrus neurons mediate self-stimulation through optogenetic activation.

The paper investigates whether simple trait measures correlate with striatal dopamine synthesis capacity and finds no significant correlations.

This study investigates how fluoxetine affects visual perception and cognitive control in macaques, showing degraded low-level vision but enhanced reward sensitivity and motivation.

This study shows that dopamine release in the lateral shell of the ventral striatum encodes visual stimulus properties like luminance changes rather than threat level in mice.

The paper investigates MMP-2 and -9 activity in the nucleus accumbens core during methamphetamine cue-induced relapse in rats, finding increased MMP activity despite stable cue-induced seeking behavior over time.

This study identifies that rILN neurons projecting to the dorsal striatum signal during action initiation and reward acquisition, influencing task success in mice.

This study shows that increased alcohol intake reduces insular cortex activity in rats, but does not change their perception of alcohol taste.

The paper introduces OpAL*, a model that demonstrates the normative advantages of dopamine and striatal opponency in learning and choice, particularly in sparse reward environments.

This study investigates the effects of brain-specific noradrenergic depletion on behavior and gene expression, finding anxiolytic effects and altered gene regulation in vulnerable brain regions.