Neurotransmitter Receptor Influence on Behavior

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

The paper shows that larger reward expectations in mice are associated with slower dopamine rise and larger dopamine dip in the ventral striatum during task performance.

The paper investigates the role of the BLA-vHC circuit in alcohol drinking behaviors using chemogenetics and finds that inhibiting this pathway reduces appetitive drinking but not consummatory behaviors.

The paper identifies a novel stress-sensitive CRH GABA projection from the basolateral amygdala to the nucleus accumbens that contributes to reward behavior disruption following early-life adversity.

This study shows female C57BL/6J mice are more resistant to footshock punishment when self-administering ethanol compared to males.

The paper inhibits norepinephrine signaling during a sensitive period in mice, revealing long-term effects on emotional behaviors and LC-NE circuitry in adulthood.

This study investigates how neuro-immune signaling and choline transporter modifications contribute to addiction vulnerability in sign-tracking rats.

This paper extends homeostatic regulation into a reinforcement learning framework to model sodium-seeking behavior and dopamine signaling in rats.

This study identifies ANKK1's role in striatal DR2-expressing neurons, linking it to reward, metabolism, and behaviors associated with the A1 allele of TaqIA.

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

This study identifies six topographically and functionally distinct regions in the mouse central nucleus of the amygdala (CeA) innervated by different dopaminergic pathways.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

This paper computationally models neuromodulator circuits to show that multiple stable architectures can produce similar network activity, demonstrating degeneracy in dopamine and serotonin systems.

This study investigates the role of infralimbic cortex projections to the nucleus accumbens shell and amygdala in cocaine extinction learning using optogenetic inhibition in rats.

This study shows that mesolimbic dopamine adjusts the rate of learning from action in mice, supporting a model where dopamine signals set an adaptive learning rate rather than serving as an error signal.

This study shows that activating presynaptic Gq-coupled receptors causes biphasic DAT trafficking, affecting dopamine clearance and motor function.

This study shows that ventral subiculum neuronal ensembles are specifically involved in the incubation of oxycodone craving after voluntary abstinence, but not after forced abstinence or early abstinence.

This study investigates how dopamine release in different striatal regions affects behavioral flexibility using optogenetics in mice.

This study identifies the role of claustrum D1RCaMKII in adolescent cocaine exposure-induced anxiety-like behaviors and shows that electro-acupuncture can alleviate these behaviors by targeting this pathway.

This study shows that dopamine release in the ventral striatum is linked to reward learning, not just reward processing, using combined PET and fMRI in humans.

The paper uses rabies virus tracing to identify drug-induced changes in connectivity to midbrain dopamine cells and links these changes to gene expression patterns.

This study investigates whether pair housing after heroin self-administration affects incubation of craving, extinction, and reinstatement in rats, finding no differences between pair-housed and single-housed rats.

This study shows that binge alcohol drinking alters how cholinergic interneurons modulate glutamate release in nucleus accumbens D1 and D2 medium spiny neurons.

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.

This study shows that Losartan, an angiotensin II type 1 receptor antagonist, alters social reward and punishment processing by modulating midbrain-striato-frontal circuits in humans.

This study examines the relationships between impulsive action, risky decision-making, and delay discounting in rats, and how they are modulated by dopamine receptor agonists.

The paper identifies brain regions associated with preference for sweet water over cocaine in rats using fos mapping, showing cocaine induces more global activation but saccharin activates regions related to taste and reward delay.

The paper tests if optogenetic stimulation of specific dopamine receptor neurons in the nucleus accumbens reduces cocaine seeking in male rats, finding it reduces seeking when targeting D2DR neurons.