Neurotransmitter Receptor Influence on Behavior

The paper maps the dopamine circuit to bacterial chemotaxis, showing it functions as a reward-taxis system using fold-change detection to explain the matching law.

This study investigates the role of dopamine D2 receptors in coordinating acetylcholine and dopamine signals in the striatum during reward-related behaviors and finds that D2Rs regulate the timing and magnitude of acetylcholine dips.

This study investigates dopamine's role in reward seeking and arousal, finding that D1 receptor antagonism affects behavior based on arousal state, while D2 receptor antagonism does not.

The paper replicates a study showing that breeding colony affects Pavlovian conditioned approach outcomes in rats, with K72 rats showing higher scores than R06 rats.

This paper shows that dopamine responses shift backward in time during associative learning, aligning with TD prediction error models.

This study shows that dopamine receptor antagonism affects Pavlovian learning differently depending on training phase and task type, with persistent deficits only in reward size tasks during the expression phase.

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

This study investigates the role of the indirect pathway in choice suppression using chemogenetic manipulation in mice, finding that activation, not inhibition, of iSPNs disrupts suppression of nonrewarded choices.

This study investigates the role of rostral medial frontal cortex in consummatory behavior using reversible inactivation and opioid receptor stimulation in rats.

This study shows that ventral pallidum GABA neurons bidirectionally control opioid relapse in rats, depending on the behavioral context and type of abstinence.

This study examines Bmal1-knockout mice, finding reduced cocaine-seeking behavior and cognitive impairments linked to altered dopamine metabolism.

This study identifies Nr4a1's role in cocaine reward by analyzing VP gene expression and manipulating Nr4a1 in specific neurons.

This study identifies a Notch1-Hes1-GABAB1 receptor pathway in the medial prefrontal cortex that mediates methamphetamine-induced psychosis by suppressing GABAB1 expression.

This study shows that activating the dorsal septum increases binge-like alcohol consumption in male mice, with sex-dependent effects on locomotor activity and sucrose drinking.

This study shows that a BD2-selective BET inhibitor reduces cocaine-seeking behavior in mice without affecting other behaviors, and alters gene expression in a domain-specific manner.

The paper shows that less flexible mice consume more ethanol, linking behavioral inflexibility to higher alcohol intake.

The paper uses a modified viral-genetic strategy to assess both local and long-range inputs to ventral tegmental area dopamine cells, revealing that nearly half of their inputs are local.

This study shows that D2 dopamine receptors in the superior colliculus modulate defensive behaviors to visual threats, with optogenetic activation promoting defensive responses and chemogenetic inhibition reducing them.

This study investigates how dopamine affects emotion recognition by testing haloperidol's effects on dynamic emotion perception, finding that outcomes depend on baseline dopamine levels.

This study identifies a midbrain dopamine projection to the amygdala that mediates cocaine withdrawal-induced anxiety and reinstatement of drug-seeking behavior.

The paper investigates how context coding in the mouse nucleus accumbens modulates motivationally relevant information during a task, finding value-independent coding for context cues.

This study shows dopamine modulates attentional processing in macaque parietal cortex by altering neuronal firing rates and gain variability.

The paper compares biased and unbiased measures of dopamine release and clearance using FSCV and finds that velocity measures provide more accurate insights into DAT activity and inhibitor effects.

This study investigates the role of D1 receptors in the nucleus accumbens core in regulating reward-seeking behavior during Go/No-Go tasks in rats.

This study performs a meta-analysis of prefrontal dopamine and D1-receptor manipulations on working memory, finding a negative quadratic relationship explaining 10% of variance.

This study examines the relationship between the resting state of the dorsal striatal cholinergic system and flexible behavior in reversal learning, finding variability in choline levels correlates with error rates and learning speed.

This study examines age and sex differences in striatal D2R availability using a large PET cohort, finding age-related decline and sex differences in D2R levels.

This study shows that fasting reduces excitability and inhibitory synaptic transmission of tVTA/RMTG GABAergic neurons, potentially allowing disinhibition of dopamine neurons.

This study shows metformin injected into the nucleus accumbens core reduces cue-induced cocaine seeking in both male and female rats without affecting locomotor activity.

The paper shows that dopamine modulates learning from primary sources, regardless of whether they are social or individual, but not from secondary sources.