Gut microbiota and health

This study examines how maternal ampicillin exposure during pregnancy and postpartum affects fecal microbiome and metabolic profiles, linking these changes to increased offspring weight gain.

The paper analyzes gut microbiome data from three countries to show diet-microbiota associations vary by location and strain.

The paper shows that specific E. coli strains reduce Salmonella colonization by utilizing galactose, offering insights for microbiota-based infection control strategies.

This study identifies Prevotella copri as a driver of MASLD progression by promoting hepatic steatosis and fibrosis through lipid accumulation and impaired intestinal tight junctions.

This study shows that gut microbiota dysbiosis caused by brain tumors affects immunotherapy efficacy, and tryptophan supplementation or Duncaniella dubosii colonization can restore microbiota and improve survival.

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

This study examines how chronic social defeat stress affects gut microbiome composition in male, female, and aggressor mice, finding stress-induced dysbiosis with sex-specific correlations.

This study maps gut microbiome associations with 37 health conditions using the Human Phenotype Project 10K cohort, identifying significant microbial abundance patterns linked to favorable health states.

This study analyzes microbiome data from multiple OA cohorts and finds no significant differences between OA patients and controls, attributing microbiome changes to age and BMI instead of OA.

MITScan performs genome-wide association analysis between microbiome and host transcriptome using zero-inflated negative binomial models, achieving computational efficiency with score tests and permutation methods.

This study shows that better adherence to LE8 metrics improves gut microbiota diversity and cognitive performance in the Framingham Heart Study participants.

The paper identifies a novel subspecies of Bifidobacterium longum, BL. nexti, in infant gut microbiomes, showing its association with formula feeding and vertical transmission.

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

The paper characterizes eukaryotic diversity in wild baboon gut microbiomes and finds social group membership explains some variation, but season, age, and sex do not.

This study evaluates machine learning algorithms and feature selection stability in multi-omics microbiome datasets, finding that nonlinear models and multi-omics integration improve predictive performance and reproducibility.

The paper introduces a model for probiotic delivery and metabolism in the gut, applied to treat trimethylaminuria by predicting required probiotic doses.

This study shows dietary fiber reduces TMAO formation after beef consumption, particularly in low meat eaters, by downregulating cutC expression.

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

This study shows that gut microbial dysbiosis drives anxiety-like behavior during morphine withdrawal and that probiotics can reduce this behavior.

The paper investigates gut microbiome-mucosal immunity interactions in wild spotted hyenas, finding age-dependent associations and identifying key taxa influencing these relationships.

This study identifies Methanobrevibacter smithii as associated with colorectal cancer through trophic interactions with CRC-causing bacteria and archaeal-derived compounds.

LAMPP provides a standardized benchmark for evaluating host phenotype prediction from gut metagenomic data, showing that traditional methods remain competitive.

VBayesMM improves identification of microbial-metabolite relationships in high-dimensional microbiome data by using a Bayesian neural network with spike-and-slab priors.

This study characterizes the lung microbiome in health and respiratory diseases using metagenomic sequencing, identifying key species and functional pathways associated with different conditions.

This study identifies elevated chenodeoxycholic acid as a poor prognostic marker in acute liver failure and shows that Bacteroides intestinalis-AM1 reduces bile acids and inflammation, improving liver injury.

This study shows that Alistipes timonensis colonization in Il10-deficient mice delays colitis by altering the host lipidome and delivering anti-inflammatory outer membrane vesicles containing immunomodulatory lipids.

This study develops a high-throughput in vitro pipeline to quantify epithelial permeability of gut bacterial metabolites and identifies new bacteria-drug pairs affecting permeability.

This study develops a biophysical model to show how diurnal variations in digestion and fluid flow drive microbial population dynamics in the human large intestine, leading to fluctuations in microbial biomass and fermentation product uptake.

This study characterizes gut microbiota composition along the gastrointestinal tract in mice under high-fat diet and prebiotic conditions, revealing species-specific responses and challenges the translational relevance of rodent models.