Parkinson's Disease Mechanisms and Treatments

This study investigates how the PINK1-G411S mutant affects PINK1 function, showing increased kinase stability and mitochondrial-linked functions through molecular dynamics analysis.

This study shows moderate intensity aerobic exercise improves motor deficits and reduces blood biomarkers in a Parkinson's rat model without increasing striatal dopamine or tyrosine hydroxylase.

This study shows that Parkinson's disease patients exert less grip force for low incentives, linking reduced motor effort to putaminal dopamine loss.

The paper examines how polygenic scores and lifestyle factors influence age at onset in Parkinson's disease, finding that lifestyle factors have a larger impact than genetic variants.

This paper develops an adaptive wheel exercise system for mice with Parkinson's disease to enable non-aversive, performance-tracked exercise and neurophysiological measurement.

The paper performs a GWAS on PSP in the Iberian population, replicates known risk variants, and identifies a novel locus in NFASC/CNTN2 associated with oligodendrocyte and myelination processes.

This study identifies excitatory synapses as primary targets of α-synuclein aggregation in a Parkinson's disease mouse model, revealing spatial and temporal patterns of synaptic vulnerability.

This study shows α-Synuclein binds lipid droplets, senses cholesteryl-ester, regulates organelle size and abundance, and links its dysfunction to neurodegenerative diseases.

This study identifies 1,111 PD-associated RNAs in blood and develops a multi-omics model with AUC 0.89 for PD diagnosis, offering insights into pathobiology and potential clinical applications.

The paper models disease progression in Lewy body disorders using neuropathological data, identifying three distinct trajectories of alpha-synuclein pathology with different clinical associations.

This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

This study shows that LRRK1 and LRRK2 are essential for dopaminergic neuron survival, as their deletion leads to age-dependent neurodegeneration in mice.

The paper uses TRAP-Bac to study translational gene expression changes in direct and indirect pathways of LDOPA-induced dyskinesia in mice, identifying pathway-specific gene expression patterns.

This study identifies six novel genetic loci associated with Parkinson's disease mortality and motor progression using genome-wide survival analysis.

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

This study examines sensory deficits in a 6-OHDA-induced Parkinson's disease mouse model, revealing varied tactile sensation impairments alongside motor and dopaminergic changes.

This study develops a PET ligand to visualize α-synuclein pathologies in Parkinson's and DLB patients, showing increased signals in affected brain regions.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

The paper evaluates aging's effect on motor and cognitive impairments in PINK1 knockout rats, finding decreased nigral dopamine and tyrosine hydroxylase with age, but not in striatum.

This study shows that alpha-synuclein aggregates are resistant to phosphatase dephosphorylation and introduces a method using calf intestinal phosphatase (CIAP) to specifically detect aggregated PSER129 in biological samples.

The paper shows that modulating perineuronal nets in the motor cortex of Parkinson's disease mice improves motor function when combined with environmental enrichment and training.

The paper evaluates extracellular miRNA signatures in plasma and CSF to distinguish LRRK2 mutation carriers from sporadic Parkinson's disease patients and healthy controls.

The paper identifies novel SNCA transcripts in human dopaminergic neurons and demonstrates their impact on antisense oligonucleotide therapy for Parkinson's disease.

This study investigates the impact of LRRK2 G2019S mutation on Wnt and NFAT signaling in Parkinson's disease models, finding significant dysregulation in specific brain regions.

The paper shows that temporarily increasing dopamine in a Parkinson's mouse model preserves motor function, neuron structure, and specific neural inputs.

This study shows that autoimmune response to alpha-synuclein antigen causes Parkinson's disease-like symptoms in mice through immune cell infiltration and inflammation.

The study tests whether GBA1 mutations or mouse genotype affect alpha-synuclein seeding in mice, finding no significant influence on seeding efficacy or pathology spread.

The paper tests cognitive deficits in PINK1 knockout rats using a modified T-maze, finding increased errors and slower performance compared to wild-type rats.

A Drosophila genetic screen identifies glial adenosine metabolism genes as therapeutic targets for alpha-synucleinopathies by improving locomotion and reducing neurodegeneration.