Epilepsy research and treatment

This study compares HFO amplitude and rate as biomarkers for seizure onset zone localization using iEEG data from 11 patients, finding amplitude provides better classification accuracy and consistency.

The paper identifies impaired state-dependent potentiation of GABAergic currents in a mouse model of IGE as a mechanism triggering seizures during sleep-like states.

This paper introduces a taxonomy of seizure dynamotypes based on bifurcation theory and applies it to EEG data, identifying 16 dynamotypes and their variations across patients.

The paper examines how seizure onset location influences electrographic patterns and identifies that specific oscillatory dynamics and interactions are more indicative of seizure origin than traditional biomarkers.

The paper analyzes spectral harmonicity in ictal activity to distinguish between harmonic and non-harmonic phase-amplitude couplings in epilepsy patients, showing its relevance for identifying seizure onset zones.

The paper analyzes seizure network dynamics in focal epilepsy patients, finding that seizure pathways change on circadian and slower timescales, independent of medication.

The paper introduces three measures to predict seizure onset patterns using interictal brain network properties from scalp EEG data.

The paper screens synthetic cannabinoids in a zebrafish model of Dravet Syndrome to identify anti-seizure compounds.

This study identifies 5HT1A and dopamine pathway activation as potential therapies for Dup15q syndrome using a Drosophila model and a compound screen.

This study evaluates the safety and accuracy of robot-assisted stereotactic electrode placement in limbic thalamic nuclei for research in patients with temporal lobe epilepsy.

The paper calculates polygenic risk scores for epilepsy subtypes in a French-Canadian cohort and finds they provide reliable genetic contribution estimates, though clinical use requires further study.

This study shows that CAE patients have higher theta and beta EEG wavelet powers than controls, which decrease after treatment, suggesting potential EEG biomarkers for diagnosis and monitoring.

This study develops a zebrafish model for Dravet Syndrome and tests compounds that selectively target Nav1.1 or Nav1.6 channels, showing both reduce seizure-like behavior.

This study shows that TLR4 signaling in neurons increases calcium-permeable AMPAR currents and promotes post-traumatic epileptogenesis, with early blockade reducing seizure susceptibility.

This study uses CRISPRa to increase Kv1.1 expression in mouse hippocampal neurons, reducing seizures and cognitive deficits in a temporal lobe epilepsy model.

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.

This study shows that UCA1 inhibits astrocyte activation and improves cognitive function in TLE rats by modulating the JAK/STAT signaling pathway.

This paper identifies EZH2 as a protective factor in epilepsy using a systems approach to analyze transcriptomic data from rodent and human samples.

The paper identifies a recurrent start codon mutation in UGP2 causing a severe epileptic encephalopathy, showing that isoform-specific expression loss of an essential gene can lead to disease.

The paper compares dual isogenic human iPSC pairs to identify functional alterations caused by an epilepsy-associated SCN1A mutation and its interaction with genetic background.

This study shows that SGK1.1 activation reduces seizure duration and mortality in a mouse model of status epilepticus by increasing M-current in hippocampal neurons.

This study uses home-cage monitoring to identify ictal and interictal behavioral changes in mouse seizure models, revealing distinct behavioral and convulsive severity profiles.

This study identifies key regulators of epileptogenesis in temporal lobe epilepsy using systems-level analysis of transcriptomic data from rodent models and human patients.

The paper develops an optogenetic intensity response procedure to measure network excitability by inducing epileptiform discharges in mice and analyzing the intensity required to trigger them.

The paper examines Wnt pathway dysregulation and neurogenesis changes in a mouse model of temporal lobe epilepsy following seizures.

This study investigates neuronal deficits in zebrafish with Scn1Lab deficiency, finding increased excitatory/inhibitory imbalance and neuron apoptosis linked to epileptiform seizures.

The paper compares two in vitro models of epileptic seizures, finding differences in glutamatergic involvement and seizure-like event characteristics.

This paper uses computational models to identify optimal resection strategies for epilepsy by quantifying ictogenic zones in brain networks.

The paper introduces the connectivity index (CI) to grade epileptogenicity by analyzing evoked responses to electrical stimulation and finds higher CI in seizure onset zones compared to controls.

This paper introduces a rat model of somatosensory stimulation-induced reflex seizures that occur without brain damage and can be used to study seizure mechanisms and drug responses.