Epilepsy research and treatment

The paper reports the presence of spike-wave discharges (SWDs) in Lister Hooded rats and their pharmacological modulation using GABA-B agonists and anti-seizure drugs.

This study identifies factors influencing beliefs and attitudes towards childhood epilepsy using a structural equation model in a Brazilian cultural context.

The paper develops a novel spike sorting method to analyze neuronal activity during human seizures, finding that recruited neurons show altered action potential waveforms compared to non-recruited tissue.

The paper investigates how norepinephrine synthesis and neurotransmission deficits contribute to seizure-induced respiratory arrest and identifies NE-1R as a potential therapeutic target for SUDEP prevention.

This study develops an automated method to detect high-frequency oscillations (HFOs) in long-term scalp EEG from infantile spasms patients and healthy controls, showing higher HFO rates in patients and a significant reduction after ACTH treatment.

The paper identifies ectopic HCN4 expression in FCM neurons as a cAMP-dependent seizure mechanism in TSC and FCDII, suggesting HCN4 as a gene therapy target for epilepsy.

This study investigates early-life seizures in SYNGAP1 heterozygous mice and finds that GABAergic signaling promotes seizure generation, with subclinical seizures refractory to some treatments but responsive to others.

The paper identifies synaptic reorganization in a mouse model of focal cortical malformation and shows that optogenetic stimulation of somatostatin interneurons can stop seizures.

This paper introduces a novel mouse model of focal cortical seizures using chemogenetic inhibition of GABAergic neurons, showing reliable induction of seizures with characteristics similar to human epilepsy.

This study shows that scalp EEG high frequency oscillations (HFOs) and their coupling with slow-wave activity correlate with active infantile spasms and can predict them better than hypsarrhythmia.

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

This paper identifies a KCNB1 pathogenic variant in mice that causes epilepsy and neurobehavioral abnormalities, mimicking human DEE features.

The paper identifies superhub cells in neural networks that, when targeted, more effectively stabilize epileptic networks compared to traditional hub cells.

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.

The paper identifies reduced KCNQ2/3 expression and impaired spike frequency adaptation in TLE patients and mouse models, showing their role in promoting seizure activity.

This study examines thalamocortical synchronization changes in mesial temporal lobe seizures, finding increased synchronization at onset and decreased connectivity at termination, with higher seizure burden correlating with greater synchronization.

This study investigates the role of postictal hypoperfusion/hypoxia in memory impairments after seizures, finding that synaptic plasticity is specifically affected while other network functions remain intact.

This study shows that reducing SCN2A function with an antisense oligonucleotide improves survival and behavior in a mouse model of early seizure onset DEE.

This study shows that optogenetic activation of CA1 pyramidal neurons in mice induces seizures with two distinct patterns, suggesting involvement of TLE-related networks.

The paper investigates the relationship between Bdnf transcription and histone acetylation in epilepsy, finding that Bdnf repositioning correlates with epileptic traits and is influenced by transcriptional activity and histone deacetylase inhibition.

This study compares HFO amplitude and rate as biomarkers for seizure onset zone localization using iEEG data from 11 patients, finding amplitude provides better classification accuracy and consistency.

The paper identifies a potential pathogenic STR expansion in an epilepsy cohort using whole genome sequencing and three software tools, highlighting discrepancies in variant calling.

This study shows that maladaptive myelination driven by absence seizures contributes to epileptogenesis in two mouse models of absence epilepsy.

The paper identifies impaired state-dependent potentiation of GABAergic currents in a mouse model of IGE as a mechanism triggering seizures during sleep-like states.

This study examines how GABA and carbamazepine affect seizure onset dynamics in mouse brain slices using bifurcation analysis.

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.

This paper introduces a taxonomy of seizure dynamotypes based on bifurcation theory and applies it to EEG data, identifying 16 dynamotypes and their variations across patients.

This study shows sodium valproate reduces epileptic seizures by inhibiting Lox-mediated ferroptosis in mouse models and cell cultures.