Air Quality and Health Impacts

Air pollutant multiomics improves functional annotation of SNPs associated with lung disease

The paper identifies airway epithelial transcriptional mechanisms linked to air pollutant exposure and lung disease risk using a functional genomics pipeline, highlighting hyaluronic acid metabolism and TOMM7 regulation as potential therapeutic targets.

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimers disease by chemically distinct air pollutants

This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.

Early-Life Wildfire Smoke Exposure Is Associated with Long-Term Systemic Immune Remodeling and Epigenetic Reprogramming

This study shows that early-life wildfire smoke exposure in rhesus macaques leads to long-term immune and epigenetic changes, including altered cytokine responses and accelerated epigenetic aging.

Sources of outdoor air pollution exposure and child brain network development across the United States

This study links childhood exposure to different sources of PM2.5 pollution to changes in brain network connectivity across the U.S., with regional differences observed.

A non-invasive method of air pollutant exposure in an avian model of development

This paper introduces a non-invasive method for exposing chicken embryos to carbon monoxide and demonstrates its reliability and safety for teratogenicity studies.

Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence

This study links outdoor air pollution exposure to increased perivascular space count and poorer cognition in preadolescents, suggesting brain clearance mechanisms may mediate pollution's neurotoxic effects.

Ambient Pollution Components and Sources Associated with Hippocampal Architecture and Memory in Pre-Adolescents

The paper examines how ambient air pollution components and sources affect hippocampal structure and memory in pre-adolescents using data from the Adolescent Brain Cognitive Development Study.

CD163 protects against pulmonary injury and inflammation induced by acute O3 exposure

This study shows that CD163 reduces O3-induced pulmonary injury by clearing cell-free hemoglobin (CFH), as demonstrated in mice and human samples.

Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model

The paper investigates how acute wood smoke exposure affects hippocampal transcriptomic responses in a mouse model of accelerated ovarian failure, identifying cell-type-specific transcriptional changes.

Microbiota-derived TMAO links PM2.5 exposure to cognitive impairment: A gut liver brain axis

This study shows PM2.5 exposure causes cognitive impairment via the gut-liver-brain axis, mediated by TMAO-induced ER stress in the hippocampus.

Occupationally Relevant Wildfire Smoke Inhalation Impairs Nitric Oxide Signaling and Promotes Progressive Aortic Stiffening in Hypercholesterolemic Mice

This study shows that wildfire smoke exposure in hypercholesterolemic mice causes vascular inflammation, oxidative stress, and fibrosis, leading to aortic stiffening and hypertension.

Railway Catenary Sparking as a Source of Toxic Copper Ultrafine Particles: Evidence from Realistic In Vitro Inhalation Exposure

This study investigates the toxicity of copper ultrafine particles from railway catenary sparking using in vitro lung models and finds adverse effects including inflammation and DNA damage.

Diesel exhaust particles induce lasting and age-dependent damage to the brain in Drosophila melanogaster

This study shows diesel exhaust particles cause age-dependent brain damage in fruit flies, with partial recovery in young flies but not in aged ones after exposure stops.

PM2.5 toxin benzopyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling

This study shows PM2.5 and its toxin benzo[a]pyrene induce airway inflammation and oxidative stress by up-regulating TRPC6 and inactivating β2AR/CFTR signaling.

Neighborhood air pollution is negatively associated with neurocognitive maturation in early adolescence

This study finds that high levels of PM2.5 and O3 air pollutants are associated with delayed neurocognitive maturation in early adolescents.

Prenatal diet buffers infant epigenetic changes linked to pollution and transient wheeze

This study examines how prenatal air pollution exposure affects DNA methylation in cord blood and its link to childhood wheeze, finding some epigenetic changes are partially buffered by maternal diet.

Understanding the neurocognitive impact of outdoor PM10 and PM2.5 exposure: an in silico dosimetric modeling study using MPPD

This study uses in silico dosimetric modeling to assess the neurocognitive impact of short-term PM10 and PM2.5 exposure in healthy young adults in Spain.

Urban PM2.5 Impairs Blood-Brain Barrier Integrity and Enhances LOX-1 Expression in Human Brain Endothelial Cells

This study shows urban PM2.5 exposure impairs blood-brain barrier integrity and increases LOX-1 expression in human brain endothelial cells, suggesting a mechanism linking air pollution to cerebrovascular disease.

Spatial and spectral mapping of traffic-related air pollution (TRAP) nanoparticles in relation to plaques and inflammatory markers in an Alzheimer disease model

This study maps TRAP-derived nanoparticles in an Alzheimer model, finding sex- and region-specific effects on neuroinflammation and plaque interactions.

Single-cell transcriptomics reveal alveolar macrophages-specific responses in single-hit ozone exposure model in mice

This study uses single-cell RNA sequencing to analyze alveolar macrophage responses to different ozone concentrations in mice, identifying concentration-dependent transcriptomic and functional changes.

Persistent transcriptomic changes following repeated exposure to wood smoke in non-human primate airway epithelial cells

This study identifies persistent transcriptomic and epigenomic changes in non-human primate airway epithelial cells after wood smoke exposure, revealing lasting molecular effects despite no visible histological changes.

Characterization of Woodsmoke Generated in the Air Pollution Exposure Lab and Comparison to Diesel Exhaust

This study characterizes woodsmoke generated in a lab and compares it to diesel exhaust, finding differences in chemical composition and oxidative potential.

Impact of air pollution on Neurite Orientation Dispersion and Density metrics (NODDI) in 10-13-year-old children with and without ADHD diagnosis

This study examines associations between air pollution exposure and white matter microstructure in children with and without ADHD using NODDI, finding no statistically significant results after correction.

Integrating Artificial Intelligence and Machine Learning to Forecast Air Pollution Impacts on Climate Variability and Public Health

This study uses machine learning to predict air pollution's impact on climate and health using synthetic data, showing strong predictive accuracy with ensemble models.

SEASONAL PM2.5 DIFFERENTIALLY REGULATES JAK2/STAT3 SIGNALING IN RURAL AND URBAN COHORTS

This study shows seasonal PM2.5 exposure differentially affects JAK2/STAT3 signaling and oxidative stress in urban and rural cohorts, increasing lung cancer risk in urban areas.

Woodsmoke and Diesel Exhaust: Distinct Transcriptomic Profiles in the Human Airway Epithelium

This study compares the transcriptomic effects of woodsmoke and diesel exhaust on human airway epithelial cells, showing distinct gene expression changes and pathways affected.

Sex-specific Effects of Outdoor Air Pollution on Subcortical Microstructure and Weight Gain: Findings from the ABCD Study

This study examines how air pollution exposure interacts with subcortical brain microstructure in children to influence BMI changes over two years, finding stronger associations in males.

Outdoor Air Pollution Relates to Amygdala Subregion Volume and Apportionment in Early Adolescents

The paper examines the relationship between outdoor air pollution and amygdala subregion volumes in early adolescents using ABCD Study data and finds associations between pollutants and specific subregion volume changes.

CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-ARRHYTHMIC EFFECT OF DIESEL EXHAUST PARTICLES IN ISOLATED RAT HEARTS BY REDUCING OXIDATIVE STRESS.

This study shows that cerium oxide nanoparticles reduce oxidative stress and pro-arrhythmic effects caused by diesel exhaust particles in rat hearts.

Sleep duration and efficiency moderate the effects of prenatal and childhood ambient pollutant exposure on global white matter microstructural integrity in adolescence

The paper examines how sleep duration and efficiency moderate the impact of prenatal and childhood air pollution on white matter integrity in adolescents.