Robert M. Tighe

The paper identifies CYP2B10 as the enzyme that activates BHT into a toxic quinone methide, leading to apoptosis and lung damage in mice.

This study shows that CD163 reduces O3-induced pulmonary injury by clearing cell-free hemoglobin (CFH), as demonstrated in mice and human samples.

This study identifies distinct pneumonia endotypes based on pathogen-specific host responses in the lung, linking them to clinical outcomes and suggesting personalized treatment strategies.

The paper identifies distinct peripheral PUFA metabolites associated with different causes and severity of ARDS, suggesting potential biomarkers and therapeutic targets.

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.