Pain Mechanisms and Treatments

Flavonoid chronotherapy normalizes circadian dynamics and sleep architecture in mice with painful nerve injury

This study shows that flavonoids nobiletin and tangeretin restore circadian rhythms and improve sleep in mice with neuropathic pain.

Conserved Axonal Transcriptome Dynamics Underlie PGE2-Induced Sensitisation and Identify Tnfrsf12a/Fn14 as a Regulator of Neuronal Excitability in DRG Neurons

The paper identifies a conserved axonal transcriptome involved in PGE2-induced sensitisation and shows Tnfrsf12a regulates neuronal excitability in DRG neurons.

Sex-dependent Aβ RA-Low threshold mechanoreceptors alteration in diabetic conditions

This study shows that diet-induced type 2 diabetes alters Aβ RA-LTMRs in a sex-dependent manner, with males showing sensory dysfunction and females showing no changes.

Withdrawal latency in a human hot plate analog tracks inter-individual differences in pain sensitivity

This study develops a human analog of the hot plate test to measure pain sensitivity through withdrawal latency and vigor, finding that latency correlates with inter-individual pain sensitivity differences.

Liposomal DAGLβ Inhibitor Shows Substantial Antinociceptive Potency Mediated by AMPK in a Neuropathic Pain Mouse Models

The paper demonstrates that liposomal DAGLβ inhibitor KT109 shows significantly higher antinociceptive potency in neuropathic pain models, mediated by AMPK activation.

LIF is a pro-algesic mediator in human and mouse models of arthritis-related pain

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Precision cell-state silencing of injured afferents alleviates spontaneous neuropathic pain

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

Suzetrigine-evoked analgesia is potentiated by Nav1.7 null-related opioid mechanisms.

The paper investigates how Nav1.7 loss enhances opioid signaling and analgesia, showing that suzetrigine-evoked analgesia is potentiated by RGS antagonists and low-dose morphine in inflammatory pain models.

Raf-MEK-ERK signaling mediates FLT3-induced mechanical allodynia and reduced morphine analgesic efficacy in male rodents

This study identifies Raf-MEK-ERK signaling as a pathway linking FLT3 activation to nociceptor sensitization and reduced morphine efficacy in rodents.

Differential utilization of PACAP and glutamate in parabrachial neurons shapes pain and stress

The paper investigates the differential roles of PACAP and glutamate in parabrachial neurons in shaping pain and stress responses, showing distinct effects on injury-induced hypersensitivity and inflammation-induced pain.

Intracranial electrophysiology reveals distinct neural representations of nociception and salience in the human brain

The paper uses intracranial recordings to show that nociception and salience have distinct neural representations in the human brain, with different anatomical, temporal, and functional characteristics.

Machine-assisted systematic review and meta-analysis of citrus flavonoids in streptozotocin-induced painful diabetic neuropathy

This study uses a machine-assisted approach to conduct a systematic review and meta-analysis of citrus flavonoids' effects on diabetic neuropathic pain in animal models.

Hippocampal extracellular matrix remodeling and temporally distinct glial reorganization following peripheral injury

This study examines temporal changes in hippocampal extracellular matrix and glial reorganization following peripheral injury, identifying matrix biomechanics as a regulator of microglial function.

Vertical climbing in mice: a translationally relevant measure of pain-related impact on natural behaviour

This study demonstrates that vertical climbing in mice is a reliable and translationally relevant measure of pain-related functional impairment across multiple pain models.

A comprehensive physiological dataset of pain and aversive modalities for pain biomarkers research

This paper presents a comprehensive dataset of physiological and behavioural responses to pain and aversive stimuli for biomarker research.

Neurons in the lateral spinal nucleus give rise to the spinotectal component of the anterolateral system in the mouse

The paper identifies neurons in the lateral spinal nucleus as the primary source of the spinotectal component of the anterolateral system in mice, linking them to head movement and itch responses.

Cell type-resolved connectomic reconstruction of the spinal dorsal horn reveals sensory neuron synaptic organization and modality-specific inhibition

The paper presents tools to reconstruct spinal cord circuits and identifies modality-specific inhibitory synapses between sensory neurons and inhibitory neurons.

Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

A synaptic wiring diagram underlying modality-specific ascending pathways of the superficial spinal dorsal horn

The paper maps synaptic connections in the mouse spinal dorsal horn to show how different sensory modalities are routed through distinct pathways to the brain.

Spinal microglia are dispensable for the development of opioid-induced hyperalgesia

This study shows that spinal microglia are not required for opioid-induced hyperalgesia, analgesic tolerance, or withdrawal symptoms in mice.

Forsythoside B attenuates neuropathic pain by suppressing USP7/HIF-1α-mediated microglial glycolytic reprogramming

This study shows Forsythoside B reduces neuropathic pain by inhibiting USP7-mediated HIF-1α stabilization in microglia, leading to decreased glycolytic activity and inflammation.

Satellite Glial Cells Control Sensory Neuron Excitability via the Release of Fibulin-2

This study identifies Fibulin-2 released by satellite glial cells as a regulator of sensory neuron excitability, with implications for pain management.

Endocytosis and Compartmentalized Intracellular Signaling of the Prostaglandin Receptor EP4 Mediate Pain

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

Peripheral NaV1.7 modulation reveals divergent peripheral and central adaptations in persistent trigeminal pain

This study investigates the effects of modulating the CRMP2-Nav1.7 interaction on trigeminal neuropathic pain, showing behavioral improvement without normalizing central pain circuit activity.

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

Aerobic exercise prevents the loss of endogenous pain modulation in male and female rats with traumatic brain injury.

This study shows aerobic exercise reduces chronic pain duration and preserves descending control of nociception in male and female rats with traumatic brain injury.

Superficial spinal Tac1-lineage neurons are polymodal nociceptive

This study characterizes the developmental and functional diversity of Tac1-lineage neurons in the spinal dorsal horn, showing they are polymodal nociceptive in adults.

Multispecies translational evaluation of an NMDA receptor modulator reveals analgesic, autonomic-stabilizing, and stress mitigating effects without evidence of abuse liability

This study evaluates CNS4, an NMDA receptor modulator, across mice, rats, and dogs, showing analgesic, autonomic-stabilizing, and stress-reducing effects without abuse liability.

A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability

This study identifies peripheral nociceptor hyperexcitability as a mechanism underlying pain in DM1 using a mouse model.