Hope D. Welhaven

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

This study identifies sex-specific metabolic changes in injured joints of male and female mice using MALDI-MSI and metabolomics, revealing tissue-specific and spatially dependent metabolic signatures.

This study shows that absence of complement factor D increases pressure-pain hyperalgesia in mice after medial meniscus injury despite cartilage protection.

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

This study shows that high-fat diet worsens age-related loss of bone fracture toughness in C57BL/6JN mice.

This study shows that adenine-induced kidney disease in mice alters cortical bone metabolome, with sex-dependent differences in metabolic pathways.

This study identifies metabolic pathway changes in human lung carcinoma cells infected with SARS-CoV-2, linking them to productive or non-productive viral infection.

The paper examines how 18-months of diet, exercise, or combined interventions affect the serum metabolome of knee OA patients, revealing sex-specific metabolic changes.

This study examines metabolic changes in chondrocytes under simulated microgravity, finding metabolic shifts linked to early osteoarthritis.

This study compares metabolomic profiles of healthy and osteoarthritic human cartilage to identify disease-associated metabolic endotypes and pathways.