Pregnancy and preeclampsia studies

This study investigates placental IGF1 signaling and nutrient transport in a guinea pig model of FGR with nanoparticle-mediated IGF1 treatment, showing sex-specific changes and supporting therapeutic potential.

This study examines placental transcriptome changes in a guinea pig model of placental insufficiency with and without hIGF1 nanoparticle treatment, identifying key signaling and metabolic pathways affected.

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

This study identifies TFAP2C as a critical regulator of trophoblast cell invasion and hemochorial placentation in rats, showing its role in both early development and later gestation.

This study predicts preeclampsia using first trimester vaginal microbiome data with machine learning, achieving an auROC of 0.78 in the training set and 0.80 in an independent cohort.

This study finds higher oxysterol levels in preeclamptic placentas compared to healthy pregnancies, suggesting altered cholesterol dynamics and oxidative stress in preeclampsia.

This study identifies a transposable element (TE) signature in maternal cell-free RNA that predicts preeclampsia with high accuracy.

This study establishes a new rodent model of preeclampsia by inducing intrauterine growth restriction in pregnant rats, showing elevated blood pressure and oxidative stress.

The paper links low placental Factor XIIIA1 expression with preterm birth in pregnant people living with HIV on long-term ART, suggesting ART may disrupt placental vascularization.

This study identifies transcriptome changes in the sub-placenta/decidua associated with placental insufficiency and shows that hIGF1 nanoparticle treatment alters gene expression related to trophoblast invasion and homeostasis.

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

This study investigates the association between polygenic risk scores for blood pressure traits and preeclampsia, finding shared genetic architecture but no improvement in prediction models.

The paper uses single-cell RNA sequencing to compare transcriptional differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells in early human placenta.

The paper identifies an epithelial-mesenchymal transition (EMT) mechanism in human trophoblast differentiation, linking DNA methylation changes to gene expression and invasion capacity.

This study compares transcriptomes of in vitro human placental models to bulk placental tissue, finding significant gene expression differences and developing a web tool for model selection.

This study shows that placental EVs from early-onset preeclampsia impair maternal vascular function, while those from late-onset preeclampsia have minimal effect.

This paper develops a machine-learning model using cfDNA fragmentation patterns to predict early-onset severe preeclampsia with high accuracy in early pregnancies and NIPT samples.

This study uses mouse models to show that fetal APOL1-G1 variants cause preeclampsia by inducing pro-inflammatory responses in placental and maternal monocyte cells.

This study identifies TFEB as a transcriptional regulator of syncytiotrophoblast differentiation by controlling Syncytin-1 and Syncytin-2 expression in BeWo cells.

The paper identifies 5'-tRNA fragments in preeclampsia syncytiotrophoblast vesicles that drive macrophage inflammation and endothelial dysfunction.

This study establishes a rat model to investigate early spiral arteriole remodeling in the uterine-placental interface, showing similar anatomical changes to humans before immune cell influx.

This study shows BCOR is essential for syncytiotrophoblast differentiation in mice and humans by repressing stem cell genes and alternate lineage factors.

The paper constructs an mRNA-seq atlas of human placenta across gestation, identifying extensive transcriptome changes from first to third trimester.

This study identifies and validates three bivariate extracellular miRNA biomarkers for early diagnosis and subtype distinction of preeclampsia using maternal serum samples.

This paper develops a conditional rat model to study invasive trophoblast cell lineage regulation and its role in uterine spiral artery remodeling.

This study examines how the preeclamptic environment affects cord blood-derived endothelial colony-forming cells, finding impaired function and potential for improvement with treatment.

This study shows that NOTCH3 signaling regulates human trophoblast stem cell expansion and differentiation, with implications for placental development and pregnancy disorders.

This study reviews genomic studies on cardiovascular disease progression after preeclampsia, finding heterogeneity in approaches and outcomes but common use of case-control designs.

This study identifies transcriptome differences in endometrial maturation and placental chorioamnionitis that distinguish preeclampsia subtypes and highlight competing risks.