Hearing, Cochlea, Tinnitus, Genetics

This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.

The paper examines the distribution of spiral ganglion neuron subtypes along the cochlea and their changes with aging in mice, finding a frequency-dependent pattern and age-related loss of Ic SGNs in the base.

The paper shows that XIRP2 facilitates repair of noise-induced damage to stereocilia F-actin cores in mouse auditory hair cells by enriching monomeric gamma-actin at damaged sites.

The paper shows that vestibular calyceal junction dismantlement occurs in rats with streptomycin-induced ototoxicity and in human sensory epithelia under stress, preceding hair cell loss.

This study shows that infrared laser stimulation of the cochlea can elicit and enhance auditory perception in gerbils, comparable to sound stimuli, and can be used to improve auditory prostheses.

The paper identifies STK32A as a kinase regulated by EMX2 that determines hair cell planar polarity orientation in the mouse inner ear, with STK32A promoting bundle alignment opposite to EMX2's effect.

This study shows that developmental PCB exposure impairs recovery from noise-induced hearing loss and disrupts auditory midbrain organization in mice.

The paper presents a method to generate auditory-nerve spike trains by applying a time- and interval-dependent thinning process to a Poisson process, enabling efficient simulation of neural auditory perception.

This paper investigates how barn owl nucleus laminaris neurons achieve high-frequency interaural time difference sensitivity through specific structural and dynamical mechanisms.

This study shows that a specific type of hearing loss in mice can be reversed by reactivating the Spns2 gene within a critical period, restoring auditory function and protecting hair cells.

The paper investigates how hearing loss distorts neural signal dynamics, leading to hypersensitivity to background noise, using brain recordings and deep neural networks.

This study compares human iPSC-derived inner ear organoids with early embryonic inner ear tissue, showing they recapitulate key developmental stages and marker expression.

This study shows that age-related delays in the auditory brainstem do not significantly impair complex sound representations in the midbrain of old mice with normal hearing.

The paper investigates how age-related hearing loss affects forward masking in Gaussian noise and finds older listeners with mild hearing loss are more susceptible to masker-envelope fluctuations.

This paper develops a computational model to simulate human compound action potentials (CAPs) and shows it captures key features of CAPs elicited by various stimuli.

The paper identifies a new organelle, the apicosome, specific to mouse cochlear and vestibular hair cells and describes its developmental dynamics and potential functional roles.

This study investigates how changes in parvalbumin-expressing inhibitory interneurons in the auditory cortex affect loudness perception and hyperacusis in mice.

The paper introduces HCAT, a machine learning tool for automated analysis of hair cells in cochlear images, enabling fast and unbiased counting, classification, and cochleogram generation.

The paper models homeostatic plasticity in an auditory cortex computational model to predict neural signatures of tinnitus and matches human neuroimaging findings.

The paper characterizes olivocochlear neurons during development and after sound exposure, identifying distinct subtypes and their gene expression changes, with a focus on neuropeptide-enriched subtypes that respond to acoustic trauma.

This study shows that Oncomodulin modulates spontaneous calcium signaling and afferent innervation maturation in cochlear outer hair cells during development.

The paper identifies a spontaneous mutation in the Ush1g gene in Neil1 knockout mice that causes an expanded phenotype including auditory and vestibular defects.

This study shows noise-induced synaptopathy disproportionately affects long and short sensory hair cells in the mammalian cochlea, with distinct spatial patterns of ribbon synapse loss.

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

This study models the loudness of chronic tinnitus using harmonic templates and hearing threshold data to quantify tinnitus severity.

This study examines age-related changes in dendritic morphology and synaptic innervation of bushy neurons in the cochlear nucleus, finding reduced dendritic complexity and altered synaptic input patterns associated with age-related hearing loss.

This study shows pericytes support vascular stability and spiral ganglion neuron survival through exosome-mediated VEGF-A signaling, impacting hearing.

This study identifies genetic correlations between misophonia and psychiatric disorders, showing strong links with anxiety, PTSD, and specific personality traits.

This study shows that GluA3 is essential for the proper assembly of AMPAR subunits and presynaptic ribbon morphology in cochlear synapses, leading to hearing loss in mice.

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.