Hearing, Cochlea, Tinnitus, Genetics

This study evaluates infrared laser stimulation of the cochlea from the outer ear in Mongolian gerbils, showing it can bypass middle ear function and activate the cochlea noninvasively.

This study shows that a linear BMP signaling gradient establishes radial patterning in the mouse cochlea, with SOX2 refining precision in specific regions.

The paper uses single-cell RNA sequencing to study fate conversion of supporting cells to hair cells in chick auditory epithelium, identifying a stepwise process involving precursor states and TGFβ signaling.

The paper investigates how noise injury affects mitochondrial function in spiral ganglion neurons (SGNs) by reducing expression of complexes II and IV, leading to delayed injury and degeneration.

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.

This study shows TMC1, but not TMC2, is essential for membrane remodeling in response to calcium changes, and mutations in TMC1 disrupt membrane homeostasis, leading to hearing loss.

This study shows that Runx1 regulates the diversity of auditory sensory neurons in mice, influencing their subtype identities and functional properties through postnatal plasticity.

The paper reports widespread cochlear neural damage in normal-hearing individuals and animals using physiological assays, despite no clinical hearing loss.

This study shows that salicylate increases neuronal firing in the inferior colliculus via nitric oxide signaling, suggesting a central mechanism for tinnitus.

This study introduces a biomarker using fluorescently labeled aminoglycosides in neonatal mice to assess ototoxicity and test protective therapeutics.

This study identifies differentially expressed genes associated with varying noise susceptibility in C57BL/6J mice, suggesting potential targets for gene therapy in hearing loss.

This study shows that aging leads to increased central gain in the auditory brainstem without improved neural synchrony in mice and humans.

This study shows that cochlear spontaneous activity during development is crucial for proper auditory circuit maturation, affecting frequency tuning and neural gain.

This study identifies genes and variants associated with self-reported hearing difficulty in older adults using UK Biobank exome sequencing data, finding that both common and rare variants contribute to age-related hearing loss, with sex-specific differences.

This study shows that OCM uniquely regulates intracellular Ca2+ signaling in neonatal cochlear outer hair cells by slowing Ca2+ kinetics and reducing free [Ca2+]i.

The paper analyzes single-cell RNA sequencing data from mouse cochlear supporting cells with activated ERBB2 to identify gene expression changes associated with potential hearing restoration mechanisms.

The paper compares excitation-inhibition correlations in spontaneous and tone-evoked activity in primary auditory cortex neurons of anesthetized rats, finding lower correlation in spontaneous activity.

This study identifies 53 genetic loci associated with hearing loss, including 15 novel ones, using genome-wide and exome-sequencing data from multiple cohorts.

The paper identifies rare variants in the TECTA gene associated with familial Meniere disease and suggests their impact on tectorial membrane stability.

The paper investigates the commissural projections of NPY neurons in the inferior colliculus, finding they exhibit a divergent and heterotopic pattern compared to non-NPY neurons.

This study shows that reducing activity of CaMKII+ neurons in the dorsal cochlear nucleus decreases tinnitus-like responses in mice, suggesting these neurons maintain, but do not induce, tinnitus.

The paper develops a deep multi-task multi-modal framework to classify tinnitus and predict its severity using structural MRI data, outperforming existing methods.

This study shows that changes in inner hair cell synapse density affect auditory temporal processing but not reflexes, suggesting a therapeutic approach for hearing loss.

The paper investigates short-term plasticity of MNTB-MOC synapses in mice, showing calcium and temperature sensitivity, and how tonic depression affects synaptic inhibition.

This study shows that overexpressing neurotrophin-3 in middle-aged mice prevents age-related cochlear synaptopathy and slows hearing loss.

The paper identifies a novel PLS1 variant causing autosomal-dominant hearing loss by inducing exon8 skipping and upregulating the PI3K-Akt pathway in zebrafish.

The paper shows that acoustic trauma enhances noise envelopes more than speech envelopes, impairing speech understanding in noise.

The paper identifies and characterizes spontaneous mutations causing deafness in mice from a targeted knockout program, showing these mutations are a common side effect of intensive breeding.