Hearing, Cochlea, Tinnitus, Genetics

This study identifies accelerated neural aging as a risk factor for tinnitus by analyzing MEG and structural imaging data from multiple datasets.

This study confirms the feasibility of bone conduction pABR by comparing waveforms and thresholds with air conduction in young adults with normal hearing.

This study maps T-stellate neuron connectivity and synaptic physiology to IC neurons using optogenetics and electrophysiology, revealing differences in input strength and plasticity between NPY and VIP neurons.

The paper introduces a non-invasive test to distinguish stria vascularis dysfunction from other causes of hearing loss in mice, using inter-trial coherence in auditory brainstem responses.

This study differentiates the physiological signatures of cochlear synaptopathy and inner hair cell damage using non-invasive assays in chinchilla models.

This paper introduces a mouse model of radiosurgery-induced unilateral hearing loss and shows dose-dependent hearing loss and cochlear damage.

The paper shows that aminoglycosides accumulate in the tectorial membrane, and its structural integrity affects ototoxicity.

The paper investigates age-related hearing loss by inducing cochlear synaptopathy in gerbils and testing auditory perception and neural responses to temporal fine structure.

This study identifies ESRRG as essential for normal auditory innervation and hearing by showing that its loss causes early-onset hearing loss and synaptic defects in mice.

The paper identifies an auditory brainstem response (ABR) biomarker for Alzheimer's Disease risk in rats, showing genetic risk prediction and intervention effects.

This study evaluates methods for adenoviral gene delivery to specific inner ear compartments in mice, finding that a cochleostomy approach effectively targets the scala media.

The paper identifies a cis-regulatory element, EnhancerA, and the transcription factor SIX2 that regulate tonotopic Myo7a isoform expression in cochlear hair cells, linking cochlear position to protein diversity and function.

This study shows that enhancing inhibition in the auditory cortex can reverse maladaptive plasticity in the amygdala caused by noise-induced hearing loss.

This study uses coupled oscillator models to show how entrainment and clustering affect information processing in the auditory system, revealing global encoding effects and linking nonlinear dynamics to hearing mechanisms.

The paper investigates loudness reduction in band-limited noise using a categorical-loudness-scaling paradigm and simulates results with a neural ensemble averaging model.

The paper uses a random forest classifier to distinguish neurons in two subdivisions of the inferior colliculus based on their response properties to pure tones.

The paper identifies FRMPD4 as a causal gene for X-linked non-syndromic hearing loss through genetic analysis and cross-species functional studies.

The paper identifies ADARB1 as a marker for spiral ganglion neurons and validates its use for automated counting across species.

This study characterizes age-related hearing loss in rhesus macaques through histological, physiological, and cognitive assessments, finding correlations between auditory deficits and cognitive impairments.

This paper maps the expression of whirlin across human tissues and cell types using multi-omics data, revealing its broad distribution and cell-type-specific patterns.

The paper shows dendrites in MSO neurons create internal delays that help neurons detect sound location by adjusting interaural time differences.

This study investigates binaural synchronization in green anole lizards by measuring SOAEs at both ears, finding frequency-dependent phase-locking and showing binaural coupling has greater effects than intra-ear coupling.

The paper compares immune responses during developmental spiral ganglion neuron pruning and after kanamycin-induced deafening in rats, finding distinct macrophage and T-cell dynamics in each scenario.

This study examines how hearing loss and tinnitus affect brain structure across the adult lifespan using MRI data, finding specific regional impacts and age-related changes.

This study determines the cryo-EM structure of PCDH15, revealing its right-handed double-helix dimer architecture essential for mechanotransduction.

This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.

This study compares injury-induced changes in junctional actin bands in the utricles of mice and chicks, finding differences in actin cable thickness and supporting cell expansion that may relate to regenerative capacity.

This study examines cochlear histopathology in macaques after noise-induced temporary threshold shifts, finding no significant loss of hair cells or synapses but chronic ribbon enlargement.

This study identifies immune-driven injury pathways in the cochlea during chronic suppurative otitis media using proteomic profiling in a murine model.

The paper shows that speech-like distortion product otoacoustic emissions are modulated by selective attention to speech in noise, indicating cochlear active processes contribute to auditory scene analysis.