Topic · Immunology · Immunology and Microbiology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
72 papers
Karthik Hullahalli, Katherine G. Dailey, Matthew K. Waldor
This study identifies tissue-specific bottlenecks in innate immune responses that scale with pathogen dose during E. coli infection.
Ana Milovic, Jonathan V. Duong, Alan G. Barbour
The paper compares LPS-induced transcriptional responses in white-footed deermice, mice, and rats, finding reduced interferon responses and alternative macrophage activation in deermice.
Alejandra Escós, Ester Díaz‐Mora, Michael J. Pattison…·Ana Cuenda
This study shows that p38γ and p38δ regulate innate immune responses by modulating MEF2D phosphorylation and transcriptional activity in mice.
Ofir Cohn, Gal Yankovitz, Naama Peshes‐Yaloz…·Irit Gat‐Viks
The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.
Shamila D. Alipoor, Mehdi Seyed Mirsaeidi
This study identifies two NOD2 gene variants, E778K and G908R, as increasing susceptibility to nontuberculous mycobacterial infections through computational analysis of their structural and functional impacts.
Gabriela Balderrama-Gutierrez, Ana Milovic, Vanessa J. Cook…·Alan G. Barbour
This study compares the inflammatory responses of two rodent species to LPS, finding differences in cytokine profiles and metabolic pathways that suggest infection tolerance mechanisms in the deermouse.
Abhigyan Choudhury, Nabarun Chandra Das, Ritwik Patra, Suprabhat Mukherjee
This study uses in-silico methods to analyze how SARS-CoV-2 mRNA interacts with human intracellular TLRs, identifying specific viral proteins that may trigger immune responses.
Leah M. Rommereim, Ajay Suresh Akhade, Bhaskar Dutta…·Naeha Subramanian
A small increase in NOD1 expression leads to cancer-promoting changes in cell state by promoting persistent inflammation and oncogene expression.
Virag Sharma, Nikolai Hecker, Felix Walther…·Michael Hiller
The paper identifies convergent loss of TLR5 in four mammalian lineages and shows TLR11 is also absent, suggesting reduced ability to detect extracellular flagellin.
Dipanjana Dhar, Debayan Dey, Soumalee Basu
The paper analyzes the evolution of extracellular leucine-rich repeats in metazoan Toll-like receptor 4, showing distinct clade formation and varying selection pressures across repeats.
Margaret J. Lange, Donald H. Burke, John Charles Chaput
The paper evaluates a threose nucleic acid (TNA) oligonucleotide derived from a CpG sequence and finds it induces immune responses in B cell lines with minimal effects on proliferation.
Elena Dimitrova, Leslie Ann Caromile, Reinhard Laubenbacher, Linda H. Shapiro
The paper constructs a multiscale model of TLR4 signaling in ischemic injury to predict therapeutic outcomes and identify safe targets.