Traumatic Brain Injury Research

Individualised electrophysiological neural field models for the assessment of thalamocortical function in disorders of consciousness: a multicentre study

This study uses neural field models to assess thalamocortical function in disorders of consciousness, finding reduced corticothalamic integrity in UWS compared to MCS.

Repeated Subconcussive Head Impacts Compromise White Matter Integrity and Bimanual Coordination in Collegiate Football Players

This study finds that repeated subconcussive head impacts in collegiate football players are linked to white matter microstructure changes and motor coordination deficits, not detected by standard symptom assessments.

Neuro-Metabolic and Vascular Dysregulation are Functional Biomarkers of Acquired Brain Injury

The paper evaluates neuro-metabolic and vascular dysregulation in mice post-TBI, finding sex- and injury side-dependent changes that suggest MVD as a potential biomarker.

Spontaneous slow waves index multiple dimensions of recovery in Disorders of Consciousness

This study shows that spontaneous slow waves in Disorders of Consciousness patients correlate with recovery potential and residual awareness, challenging the view of slow waves as merely a marker of impaired consciousness.

Season-long head acceleration exposure, prior contact-sport history, and cognitive performance in British amateur American football players

The study examines the relationship between season-long head acceleration exposure and cognitive performance in amateur American football players, finding no significant associations after adjustments.

Microglia modulate concussion biomarkers and cognitive recovery in male mice

This study shows microglia influence concussion recovery and identifies EV miRNA biomarkers affected by microglial presence.

Acute Temporal Dynamics of Brain Injury Plasma Biomarkers following Controlled Football Heading

This study measures plasma biomarkers after football heading to assess acute brain injury, finding significant time effects for GFAP and BD-tau but no effect of heading.

Multimodal Magnetic Resonance Imaging Biomarkers of Pediatric Traumatic Brain Injury Identified by Ensemble Learning Are Associated with Psychopathology

The paper uses ensemble learning on multimodal MRI data to identify biomarkers of pediatric TBI linked to psychopathology, finding a significant association in TBI patients.

Sport-Related Concussion in Adolescent Athletes is Associated with Acute White Matter Alterations, Delayed Network Changes, and Individual-Level Injury Patterns

This study finds that adolescent athletes with sport-related concussions show acute white matter changes and delayed network-level disruptions, with sex-specific injury patterns.

Traumatic Brain Injury Associated with Altered Corpus Callosum Microstructure in Females: Exploring the Roles of Menopause Timing and Hormone Therapy in UK Biobank

This study examines how traumatic brain injury (TBI) affects corpus callosum microstructure in females, with findings showing that menopause timing and hormone therapy duration influence these effects.

Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer's disease

This study investigates the effects of repeated mild traumatic brain injury on sleep, epileptiform activity, and Alzheimer's disease pathology in a knock-in mouse model one month post-injury.

Subacute and Chronic Cognitive and Cerebrovascular Functional Consequences of Mild Traumatic Brain Injury in Rats

This study examines cognitive and cerebrovascular impairments in rats after mild traumatic brain injury (mTBI) and evaluates the effect of aerobic exercise on these impairments at subacute and chronic stages.

Persistent Hypersensitivity after Repeat Concussion is Associated with Chronic Cognitive Dysfunction

This study shows that chronic sensory hypersensitivity after repeat concussion contributes to cognitive deficits under increased sensory load in mice.

Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury

This study shows that deleting transglutaminase 2 improves metabolic support from astrocytes and reduces pathology after repetitive mild traumatic brain injury.

PERK Deficiency Amplifies Molecular, Structural, and Network Vulnerability to Repetitive Mild Traumatic Brain Injury

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

Aging reveals domain-specific vulnerability to the chronic behavioral consequences of repetitive mild traumatic brain injury

This study investigates how aging affects the chronic behavioral consequences of repetitive mild traumatic brain injury (rmTBI) in mice, finding age-specific effects on anxiety but not spatial memory.

Headbutting goats self-inflict traumatic brain injury

This study shows that headbutting goats accumulate neurodegeneration biomarkers in CSF and brain tissue, suggesting repetitive head impacts may lead to early neurodegenerative changes.

Critical dynamics in spontaneous EEG predict perturbational complexity in disorders of consciousness with measurable evoked responses

The paper shows that resting-state EEG criticality features predict perturbational complexity index (PCI) in disorders of consciousness, but only in specific patient subgroups.

Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens

This study shows frontal brain injury reduces reward-predictive cue sensitivity and remodels the nucleus accumbens, leading to impaired decision-making and potential psychiatric symptoms.

Longitudinal multimodal neuroimaging after traumatic brain injury

This study uses longitudinal multimodal neuroimaging to analyze changes in brain injury biomarkers over time, revealing dynamic relationships between structural, functional, and PET-derived measures.

Multisensory integration in Peripersonal Space indexes consciousness states in sleep and disorders of consciousness

The paper identifies a neural marker of peripersonal space (PPS) integration in EEG data and shows its presence correlates with conscious states in sleep and disorders of consciousness.

Subconcussive preconditioning prevents microglial morphology changes and improves cognitive outcomes in mice

This study shows that subconcussive impacts before concussion reduce microglial changes and cognitive deficits in mice, but only if given within 2 minutes of injury.

Mild traumatic brain injury alters function in the dorsolateral prefrontal cortex: a TMS-EEG study.

This study investigates how mild traumatic brain injury affects neurophysiological functions in the dorsolateral prefrontal cortex using TMS-EEG, finding reduced inhibition and plasticity with some contradictory spectral responses.

Repetitive mild traumatic brain injury causes neuronal damage in the APP/PS1 mouse model of Alzheimer's disease without an enduring impact on amyloid pathology, sleep, or epileptiform activity

Modeling Sex Differences and Neurodegeneration in Repetitive Traumatic Brain Injury Using Drosophila

This paper develops a Drosophila model of repetitive traumatic brain injury to study sex-specific behavioral, proteomic, and neurodegenerative outcomes.

Neuronal p38α knockout protects against neurological consequences following repetitive mild traumatic brain injury

This study shows neuronal p38α knockout reduces neurological and immune consequences of repetitive mild traumatic brain injury in a sex-dependent manner.

Male mice are particularly vulnerable to cognitive impairment following mTBI

This study investigates cognitive impairments in male and female mice after mild TBI, finding sex-specific deficits in interval timing and novel object recognition.

Distinct Neural Signatures of Auditory Processing in Contact versus Non-contact Sports Athletes

The paper identifies reduced cortical N100 amplitudes in contact sports athletes as a biomarker of sub-concussive head impact exposure using EEG.

Proteomic Analysis of Human Chronic Traumatic Encephalopathy Brain Implicates Proteasome and Ribosome Dysfunction in Disease Progression

This study identifies proteomic changes in CTE brains, linking proteasome and ribosome dysfunction to disease progression and clinical features.

Injury-induced CTE-like pathology emerges in a human multicellular in vitro brain model and reveals mitochondrial and neurovascular regulation.

This paper develops a human multicellular in vitro brain model that mimics CTE-like pathology after mechanical injury and identifies mitochondrial and neurovascular dysregulation as key features.