Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens
Erskine Chu, Jenna E McCloskey, Mia A. Eleid, Sathvik Jami, Alexandra G. Dorinsky, Fikir B. Arega, Kris M. Martens, Fangli Zhao, Jonathan M. Packer, Patrick Stevens, Maciej Pietrzak, Candice C. Askwith, Jonathan P. Godbout, Cole Vonder Haar
This study shows frontal brain injury reduces reward-predictive cue sensitivity and remodels the nucleus accumbens, leading to impaired decision-making and potential psychiatric symptoms.
bioRxiv · Apr 19, 2026 · PreprintNeuroscience