Reproductive tract infections research

This study shows HIV-1 and Chlamydia trachomatis restrict each other's growth in co-infected human macrophages but enhance host survival.

This study examines the cervicovaginal microbiome of HIV-positive pregnant people in the DRC, finding taxonomic and functional differences compared to HIV-negative individuals and linking microbiome features to adverse pregnancy outcomes.

This study shows that female sex hormones enhance gonococcal colonization at the endocervix by altering mucus production and structure, increasing bacterial microcolony size and number.

The paper identifies CpoS as a key effector for maintaining Chlamydia trachomatis vacuole integrity by regulating sphingolipid supply and shows that disrupting this pathway can clear infection without harming host cells.

This study investigates host-microbe interactions in early pregnancy by analyzing vaginal bacteria, immune responses, and metabolic profiles to identify markers of adverse outcomes.

This study uses single-cell RNA sequencing to investigate how Chlamydia persists in the gut of mice, revealing disruptions in epithelial tight junctions and immune-cell interactions.

This study compares the genomics of seven Trichomonas species, revealing convergent genome size expansions in human-infecting lineages and genes involved in host-switching from birds to humans.

This paper develops a microphysiologic model of the cervical epithelium that replicates microbial, immunologic, and pathogenic features of STIs caused by Chlamydia and Neisseria.

This study identifies miRNA dysregulation in vaginal dysbiosis linked to HIV risk by targeting the HIV-host interactome.

The paper conducts a GWAS to identify genetic polymorphisms associated with vaginal microbiota diversity in French women using data from the PAPCLEAR cohort.

The paper develops three liquid media formulations to support rapid growth of Lactobacillus iners and other vaginal bacteria, enabling in vitro studies of their interactions.

This study examines the vaginal microbiome and immune markers before, during, and after metronidazole treatment for bacterial vaginosis, identifying distinct phases and highlighting the need for probiotics to maintain microbial balance.

This study shows that Trichomonas vaginalis extracellular vesicles suppress IFNϵ-mediated protection against host cell cytolysis by down-regulating interferon-epsilon and type I interferon responses.

The paper evaluates probiotic candidates for vaginal health using metabolic models and experimental assays, finding that D-lactic acid production, not metabolic similarity, drives inhibition of G. vaginalis.

This study uses a murine menstruation model to show that NK cell infiltration during endometrial remodeling protects against Chlamydia muridarum infection.

The paper evaluates a pathogenicity-attenuated Chlamydia muridarum mutant, intrOv, showing it fails to establish productive infection at low doses but recovers similarly to wild-type by day 7.

This study examines how maternal age influences the link between vaginal microbiota and preterm birth, finding age mediates this relationship differently across racial groups.

This study identifies distinct gene expression patterns in Chlamydia trachomatis developmental stages and shows T3SS genes are cell type restricted.

This paper identifies TmeA's role in promoting Chlamydia trachomatis invasion by interacting with N-WASP and TOCA-1 to facilitate pedestal formation.

This paper develops a transformation protocol for Gardnerella vaginalis using a Bifidobacterium-E. coli shuttle vector plasmid, demonstrating plasmid maintenance and gene expression in this organism.

This study shows that Trichomonasvirus species are unevenly distributed within individual Trichomonas vaginalis cells, challenging previous assumptions about their uniform distribution.

This study investigates how bacterial vaginosis alters cervicovaginal immunity, identifying immune cell changes that may contribute to increased HIV susceptibility.

This study compares metabolomic profiles of key vaginal microbes in planktonic and biofilm states, revealing species-specific metabolic shifts and growth mode-dependent differences.

This study profiles vaginal microbial communities in Chilean women using full-length 16S rRNA sequencing and self-sampling, revealing Lactobacillus dominance and CST IV patterns.

This study compares first-void urine and cervicovaginal brushes to vaginal swabs for microbiome profiling in ten women, finding comparable results but highlighting storage effects and the need for optimized self-sampling techniques.

This study introduces VIRGO2, an enhanced gene catalog for the vaginal microbiome, revealing new bacterial species, mycobiome features, and gene expression patterns.

This study performs a comprehensive pangenome analysis of 153 Gardnerella genomes to uncover genetic diversity, virulence factors, and antibiotic resistance genes, highlighting the need for precise species-level identification.

The paper uses 16S rRNA gene sequencing to characterize vaginal microbiomes in BV-diagnosed samples, showing strong concordance with PCR-based tests and identifying BV-associated microbial and metabolic signatures.

This study shows that Lactobacillus crispatus enrichment in the vaginal microbiota of non-human primates reduces systemic inflammation and increases anti-CT IgG production during Chlamydia trachomatis infection.