Memory and Neural Mechanisms

Artificial Reactivation of a Cocaine-Associated Ensembles in the Dorsal Dentate Gyrus Attenuates Cocaine Prime-Induced Reinstatement of Drug-Seeking

This study shows that reactivating specific cocaine-associated memories in the dorsal dentate gyrus can reduce cocaine-induced reinstatement of drug-seeking behavior, with effects varying by the stage of drug exposure.

Aging alters the distribution, stability, and transcriptional signature of engram cells

The paper examines how aging affects engram cell distribution, stability, and gene expression in mice, finding altered engram allocation and distinct transcriptional patterns in aged brains.

Representational geometry of punishment learning across basolateral amygdala neurons

This study examines how basolateral amygdala neuron activity changes during punishment learning in mice, showing that punishment learning alters action-related activity to align with punisher-specific responses.

Hippocampal replay repairs the cognitive map for flexible planning

This paper proposes that hippocampal replay repairs the cognitive map by updating it for new goals and maintaining abandoned ones, supported by rat foraging experiments.

Projection Neurons from Infralimbic (IL) to the Basolateral Amygdala (BLA) are Critical for the Expression of Social Familiarity induced Anxiolysis (SoFiA) in rats

The paper investigates the role of infralimbic to basolateral amygdala projection neurons in social familiarity-induced anxiolysis in rats using chemogenetics.

Intrinsic Cellular Persistent Firing Sustains Hippocampal Spatial Representations during Working Memory

The paper shows that hippocampal place cells maintain spatial information through intrinsic persistent firing via TRPC4 channels during working memory tasks in mice.

Gamma and theta-burst stimulation of the hippocampus and entorhinal area transiently disrupts memory

This study tests 50-Hz and theta-burst stimulation of the hippocampus and entorhinal area in monkeys and finds no memory enhancement, but significant transient memory disruption across multiple conditions.

Reward changes the use and structure of predictive spatial maps

This study investigates how reward influences hippocampal spatial maps by separating its effects on map usage and structure through a two-pathway model.

Lysine Crotonylation Acts as an Epigenetic Switch for Glutamate Neurotransmission and Spatial Memory

This study identifies lysine crotonylation (Kcr) as an epigenetic regulator of long-term memory and glutamatergic neurotransmission, showing its role in gene expression and synaptic function.

A new neural code for position: generalizable spatial maps in mouse medial frontal cortex

The paper identifies a novel neural code in the mouse medial frontal cortex that supports spatial generalization through extrapolation of coordinates across regions.

Ligand-Specific Effects of 5-HT2A Receptor Antagonists on Fear Extinction in C57BL/6J Mice: Comparative insights from MDL 11,939 and MDL 100,907

This study compares the effects of two 5-HT2A receptor antagonists on fear extinction in mice, finding ligand-specific and dose-dependent impacts on extinction learning.

Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success

The paper shows that specific amygdala neurons in humans fire more during encoding of items later remembered, predicting episodic memory success, particularly in the right amygdala.

A canonical input to the head direction compass carries predominantly eye movement signals

This study challenges the canonical view of the nucleus prepositus hypoglossi as an angular head velocity relay by showing its neurons predominantly encode eye movements rather than head motion.

Scalp EEG detects motor sequence replay signatures during wakeful rest

This study shows scalp EEG can detect motor sequence replay during wakeful rest, with accelerated memory reactivation enhancing learning and replay strength.

Manifolds for the neural representation of 3D spatial experience

The paper develops a framework using SE(3) manifolds to model 3D spatial representations in neural systems across species.

The Intermediate Hippocampus Integrates Shock-Observation and Spatial Information during Observational Fear Memory

A molecularly defined recurrent CA3 circuit regulates network dynamics and spatial working memory

This study identifies a molecularly defined CA3 neuronal population and shows its role in recurrent circuit function, network dynamics, and spatial working memory.

Encoding activity predicts distinct recognition signals during working and long-term memory in the human hippocampus

High-dimensional hippocampus representation facilitates learning of low-dimensional abstract representation and supports generalization

This paper shows that high-dimensional hippocampal representations aid in forming low-dimensional abstract representations and improve generalization.

Firing rate adaptation in grid cells produces macroscopic hexadirectional modulation

The paper investigates the neuronal origin of hexadirectional modulation in grid cells using data from foraging rats, finding that firing rate adaptation explains the phenomenon.

Forward reactivation in human hippocampal CA1 supports repetition learning and is preserved in the aging brain

The paper uses fMRI and representational similarity analysis to show that forward reactivation in hippocampal CA1 supports repetition learning and is preserved in aging.

An extracellular substrate for the temporary storage of memories

The paper identifies aggrecan as an extracellular matrix protein that stabilizes fear memories by altering neuronal excitability in the hippocampal dentate gyrus.

Post-Learning Reactivation of Memories for Naturalistic Continuous Experiences

This study shows that memories of complex narrative events are spontaneously reactivated during rest, but reactivation is linked to gist-like recall rather than strengthening episodic memory details.

The role of contextual similarity on brain activity patterns for associated events

The paper investigates how varying degrees of contextual similarity affect brain activity patterns for related events using fMRI and audiovisual stimuli.

Constricted pupil states index neural replay during wakeful rest in humans

This study links constricted pupil states to neural replay during wakeful rest in humans, showing their association with motor learning outcomes.

Coordinated cerebellar-midbrain activity for predictive signaling during fear learning in mice

The paper shows that vlPAG/DRN and FN neurons coordinate activity during fear learning in mice, supporting their functional interaction in threat prediction.

Opposing reward-epoch population coding in anterior insular cortex dissociates sign- and goal-tracking despite equivalent conditioned responding

This study identifies distinct population coding patterns in the anterior insular cortex of sign- and goal-tracking rats during reward epochs, despite equivalent conditioned responding.

The human hippocampus retroactively binds experiences across time

The paper shows that hippocampal high-frequency activity predicts later memory when a second event arrives, reinstate preceding stimuli, and is coupled to successful encoding.

Generalized prefrontal task-progress sequences efficiently encode task structure

This study shows that prefrontal cortex activity forms task-progress sequences that encode task structure efficiently, with artificial networks replicating this encoding and disruption impairing learning.

Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

This study shows that stable graded representations of threat value persist in the prelimbic cortex despite ensemble turnover during fear learning.