Author
Christian Keysers
Netherlands Institute for NeuroscienceORCID 0000-0002-2845-5467Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 6/yrCo-Author Collaboration Network
10 top collaborators · 24 mutual co-author links27 papers
Recent·Most cited
- NeuroscienceNature CommunicationsPeer-reviewedDOI 10.1038/s41467-026-78482-0
- NeuroscienceNature CommunicationsPeer-reviewed
Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula
Mijin Kwon, Ke Bo, Rotem Botvinik‐Nezer…·Feng Zhou
The paper identifies convergent and selective functional zones in the insula using fMRI data, revealing a hierarchical convergence architecture across pain, appetitive, aversive, and cognitive control domains.
- NeurosciencebioRxivPreprint
Modeling behavior to disentangle motion-related effects in functional ultrasound imaging in awake, head-fixed mice
Chaoyi Qin, Flora Nelissen, Rick Waasdorp…·Valeria Gazzola
This paper introduces a behavior-informed modeling framework to account for motion-related confounds in functional ultrasound imaging during naturalistic behaviors in awake mice.
- NeurosciencebioRxivPreprint
Dissociable Effects of Early and Adolescent Adversity on Emotional Contagion
Paloma P. Maldonado, Erica Berretta, Viviana Canicatti…·Rajeev Rajendran
This study examines how early and adolescent adversity differently affect emotional contagion in rats, finding distinct effects on observer-to-demonstrator and demonstrator-to-observer emotional transfer, with sex-specific pathways.
DOI 10.64898/2026.01.29.702530 - Animal Behavior & CognitionbioRxivPreprint
Heightened Play following Play Observation in the Absence of 22KHz Calls in Juvenile Rats
Frédéric Michon, E. J. Marijke Achterberg, Lena V. Kaufmann…·Christian Keysers
This study investigates positive emotional contagion in juvenile rats through play observation, finding increased play behavior after observing playful demonstrators without 22 kHz calls.
DOI 10.64898/2025.12.31.697143 - NeurosciencebioRxivPreprint
Representational geometry of emotional empathy in the ventromedial prefrontal cortex and in the mid-posterior insula.
Leonardo Cerliani, Rune Bruls, Cas J.S. Teurlings…·Christian Keysers
The paper investigates how brain regions encode emotional facial expressions using representational similarity analysis, finding that vmPFC and mid-posterior insula encode emotion categories and arousal+valence better than arousal alone.
- NeuroscienceCommunications BiologyPeer-reviewed
Endogenous opioid receptor system mediates costly altruism in the human brain
Jinglu Chen, Vesa Putkinen, Kerttu Seppälä…·Lauri Nummenmaa
The paper investigates how the endogenous opioid receptor system influences altruistic costly helping by linking MOR availability to brain activity during vicarious pain and helping behavior.
- NeuroscienceScientific ReportsPeer-reviewed
Neural mechanisms of costly helping in the general population and mirror-pain synesthetes
Kalliopi Ioumpa, Selene Gallo, Christian Keysers, Valeria Gazzola
The paper examines how mirror-pain synesthetes and non-synesthetes differ in their willingness to help others in pain, using fMRI to link brain activity to donation decisions across different pain-conveying modalities.
- NeuroscienceNeuroImagePeer-reviewed
A multivariate brain signature for reward
Sebastian P. H. Speer, Christian Keysers, Judit Campdepadrós Barrios…·Valeria Gazzola
The paper develops a Brain Reward Signature (BRS) using a LASSO-PCR model to predict reward and loss processing from brain activity, achieving high decoding accuracy across multiple tasks and samples.
33 citationstop 4% - NeurosciencebioRxivPreprint
Predictive coding during action observation revealed by human electrocorticographic activity
Chaoyi Qin, Frédéric Michon, Yoshiyuki Onuki…·Christian Keysers
The paper uses ECoG to study how the action observation network integrates information during action observation, finding top-down beta and bottom-up gamma oscillations in predictable and unpredictable actions respectively.
2 citations - NeuroscienceeLifePeer-reviewed
Intracranial human recordings reveal intensity coding for the pain of others in the insula
Efe Soyman, Rune Bruls, Kalliopi Ioumpa…·Valeria Gazzola
The paper uses intracranial recordings to show that the insula encodes pain intensity from different stimuli with distinct spatial and temporal coding patterns.
25 citationstop 4% - NeuroscienceeNeuroPeer-reviewed
Commanding or being a simple intermediary: how does it affect moral behavior and related brain mechanisms?
Émilie A. Caspar, Kalliopi Ioumpa, Irene Arnaldo…·Christian Keysers
This paper investigates how commanding or acting as an intermediary affects moral behavior and brain mechanisms, finding no difference in agency between commanders and intermediaries but a neural response difference when agents are robots versus humans.
- NeuroscienceCortexPeer-reviewed
Predictive coding during action observation - a depth-resolved intersubject functional correlation study at 7T
Leonardo Cerliani, Ritu Bhandari, Lorenzo De Angelis…·Christian Keysers
The paper uses intersubject functional correlation with 7T fMRI to show that predictable action sequences trigger more feedback input to parietal regions than unpredictable ones.
- NeuroscienceNeuroImagePeer-reviewed
Obeying orders reduces vicarious brain activation towards victim's pain
Émilie A. Caspar, Kalliopi Ioumpa, Christian Keysers, Valeria Gazzola
The paper shows that obeying orders reduces vicarious brain activation related to others' pain and decreases feelings of guilt and responsibility.
- NeurosciencebioRxivPreprint
Parametric tests for Leave-One-Out Inter-Subject Correlations in fMRI provide adequate Type I error control while providing high sensitivity
Lorenzo De Angelis, Valeria Gazzola, Christian Keysers
This paper evaluates parametric tests for leave-one-out inter-subject correlations in fMRI, showing they control Type I error and are sensitive for detecting neural synchronization.
- NeurosciencebioRxivPreprint
Neuro-computational mechanisms of action-outcome learning under moral conflict
L. Fornari, Kalliopi Ioumpa, Alessandra D. Nostro…·Valeria Gazzola
The paper investigates action-outcome learning in moral conflicts using reinforcement learning models and fMRI, finding that model-based learning explains choices and reveals neural biases in valuing self-gain versus other-pain.
- NeurosciencebioRxivPreprint
Multiband acceleration can provide moderate improvements in single-subject voxel-wise statistics in block-design task-based fMRI
Ritu Bhandari, Valeria Gazzola, Christian Keysers
This study shows that MB4 acceleration improves single-subject voxel-wise statistics in fMRI, with moderate effect sizes in the action observation network, but may over-penalize temporal autocorrelation.
1 citation - NeurosciencebioRxivPreprint
Bayesian statistics show a lack of change in excitability following bi-hemispheric HD-TDCS over the primary somatosensory cortices
Selene Gallo, Thijs J. Baaijen, Judith Suttrup…·Valeria Gazzola
This study uses Bayesian analysis to show that a new HD-tDCS protocol does not reliably modulate somatosensory cortex excitability across participants.
DOI 10.1101/814780 - NeurosciencebioRxivPreprint
Harm to others acts as a cingulate dependent negative reinforcer in rat
Julen Hernandez-Lallement, Augustine Triumph Attah, Valeria Gazzola, Christian Keysers
The paper demonstrates that rats exhibit harm aversion when choosing a lever that harms another rat, with anterior cingulate cortex involvement.
1 citation - NeuroscienceBrainPeer-reviewed
Action perception recruits the cerebellum and is impaired in spinocerebellar ataxia patients
Abdel R. Abdelgabar, Judith Suttrup, Robin Broersen…·Valeria Gazzola
This study shows that observing others' hand actions activates specific cerebellar regions and that SCA6 patients have impaired ability to perceive these actions.
- NeurosciencebioRxivPreprint
Does higher sampling rate (Multiband + SENSE) benefit the detection of task correlated BOLD for cognitive neuroscience applications at 3T?
Ritu Bhandari, Evgeniya P. Kirilina, Matthan W.A. Caan…·Valeria Gazzola
This study evaluates if higher multiband (MB) acceleration improves BOLD signal detection in cognitive tasks, finding MB4 provides better group-level results than lower acceleration.
- NeuroscienceSocial Cognitive and Affective NeurosciencePeer-reviewed
Measuring shared responses across subjects using intersubject correlation
Samuel A. Nastase, Valeria Gazzola, Uri Hasson, Christian Keysers
This paper introduces intersubject correlation analysis to measure shared neural responses across subjects in naturalistic scenarios.
415 citationstop 1% - NeuroscienceCurrent BiologyPeer-reviewed
Emotional Mirrors in the Rat’s Anterior Cingulate Cortex
Maria Carrillo, Yinging Han, Filippo Migliorati…·Christian Keysers
The paper identifies mirror-like neurons in the rat's anterior cingulate cortex that encode both self-experienced pain and witnessed pain in others, but not fear.
228 citationstop 1% - NeurosciencebioRxivPreprint
Cingulate dependent social risk assessment in rats
Yingying Han, Rune Bruls, Rajat Mani Thomas…·Christian Keysers
This study shows that rats exhibit bidirectional distress transmission regardless of familiarity, with cingulate-dependent mechanisms influencing both observer and demonstrator behavior.
2 citations - NeurosciencebioRxivPreprint
Perceiving Hesitation requires both the Motor and Mentalizing systems
Marc Thioux, Judith Suttrup, Christian Keysers
The paper shows that detecting hesitation in others' actions involves both mentalizing and mirror neuron systems, with motor information necessary for attributing mental states.
- NeuroscienceCerebral CortexPeer-reviewed
Representing Multiple Observed Actions in the Motor System
Emiel Cracco, Christian Keysers, Amanda Clauwaert, Marcel Braß
This study shows the motor system can represent multiple observed actions through fMRI, revealing a mechanism for processing social interactions.
- NeuroscienceNeuroImagePeer-reviewed
Where and how our brain represents the temporal structure of observed action
Rajat Mani Thomas, Teresa De Sanctis, Valeria Gazzola, Christian Keysers
This study uses fMRI and EEG to show the brain encodes sequence-specific motor information for predictable action sequences, suggesting the motor system implements perceptual predictive coding.