Nerve injury and regeneration

This study maps BDNF-specific corticostriatal circuits in mice, revealing distinct projections from different cortical regions to the dorsomedial and dorsolateral striatum.

The paper investigates how post-injury born oligodendrocytes integrate into the glial scar and inhibit axon regeneration by premature myelination.

This study shows that preconditioning with lens injury enhances optic nerve regeneration without genetic manipulations, achieving full-length regeneration through immune-related mechanisms.

This study identifies TIR-1/SARM1 as a dual regulator that inhibits axon regeneration while promoting degeneration, revealing distinct pathways for each function.

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.

This study identifies proteomic changes in human sural nerve after transection injury, revealing upregulated and downregulated proteins associated with regeneration and degeneration.

The paper identifies glial TGFβ signaling as essential for axon survival and shows its loss leads to age-dependent neurodegeneration.

This study shows that overexpressing eEF1A2 promotes corticospinal axon sprouting after injury by enhancing protein synthesis, mTOR signaling, and actin rearrangement.

The paper uses STED microscopy to analyze MPS formation in axons and regenerating axons, finding faster MPS development in regenerating axons and effects of calpain inhibition.

The paper investigates how modulating neuronal activity with opto- or chemogenetics affects axonal growth after injury, finding that growth is enhanced only on permissive substrates.

This study develops a photo-switchable assay to study dendrite degeneration and repair in Drosophila, revealing that WldS and dSarm1 modulation affects dendrite recovery.

This study investigates whether injury-induced enhancers in Schwann cells are pre-programmed or activated de novo, and identifies JUN's role in regulating these enhancers to drive repair gene expression.

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

This study investigates the roles of DLK and LZK in axon regeneration and sprouting in zebrafish neurons, finding context-dependent effects on different neuron types.

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

This study shows that co-targeting B-RAF and PTEN in adult mice enhances dorsal column axon regeneration across and beyond spinal cord injury.

This study shows that miR-182-5p downregulates Nogo-A expression and promotes neurite outgrowth in hippocampal neurons, suggesting its potential as a therapeutic tool for CNS regeneration.

This study identifies Inpp5k as a novel axon growth activator that enhances sprouting of corticospinal tract axons after CNS trauma by increasing cofilin activity and actin polymerization.

This study identifies midbrain-derived glial factors upregulated after hemispherectomy that promote ectopic cortico-mesencephalic axonal projections.

This study compares vascularized and non-vascularized nerve grafts in animal models, finding better nerve recovery in vascularized grafts but with some results being sensitive to analysis.

This paper applies optical tissue clearing to study nerve regeneration in rats, enabling 3D morphological analysis of nerves and their targets with high precision and speed.

This study shows that Transthyretin (TTR) promotes axon growth by regulating microtubule dynamics and tubulin acetylation, with restoration of acetylated tubulin rescuing defects in TTR knockout mice.

This study shows that retinoic acid treatment increases macrophage numbers and phagocytic activity, which enhances axonal regeneration after optic nerve injury in frogs.

This paper describes a novel experimental model for double nerve transfers to a single target muscle in rats, showing successful reinnervation without functional deficits.

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.