Migraine and Headache Studies

The paper identifies three dimensions linking migraine symptoms to brain functional connectivity using CCA and RSFC, revealing novel network targets and patient subtypes.

The paper validates a computational framework for modelling ion electrodiffusion during cortical spreading depression using experimental comparisons.

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

The paper identifies cyclic changes in intrinsic brain networks during the migraine cycle using fMRI, showing connectivity peaks before headaches and drops during attacks.

This study uses MEG to show increased gamma power and reduced alpha-gamma phase-amplitude coupling in primary visual cortex of visual snow syndrome patients, suggesting hyperexcitability and disrupted rhythmic activity.

This paper develops an in vitro method to record and image spreading depolarizations and seizure-like events in mouse hippocampal slices without focal stimulation.

This study identifies a neocortex-specific mechanism of cortical spreading depression (CSD) initiated by hyperactivity of GABAergic neurons and NaV1.1 channel gain-of-function, linking it to Familial Hemiplegic Migraine type-3.

The paper assesses the role of ipRGCs and cones in reflexive eye closure as a measure of photophobia in migraine, finding enhanced responses in MwA compared to other groups.

The paper investigates gene expression changes during spontaneous migraine attacks and identifies differentially expressed genes and pathways associated with migraine pathophysiology.

This study shows HDAC6 inhibition restores neuronal complexity in chronic migraine models, suggesting it as a potential therapeutic target.

This study shows PACAP induces light aversion in mice independently of CGRP, with inheritable responder and nonresponder phenotypes and distinct gene expression patterns.

This study identifies Kcnq2/Kv7.2 as a gene modulating spreading depolarization threshold and bilateral symmetry, with implications for epilepsy and migraine.

This study investigates brain activity changes during migraine cycles, finding cyclic perfusion in the limbic circuit and hypothalamic connectivity shifts, suggesting the hypothalamus drives migraine attacks by losing control over the limbic system.

The paper identifies a direct trigeminal ganglion-to-parabrachial connection that processes dura inputs, suggesting a role in migraine pathogenesis.

The paper identifies non-canonical glutamate signaling in a migraine model, linking it to spreading depolarizations and potential therapeutic targets.

This study investigates whether spreading depolarizations (SDs) and periinfarct depolarizations (PiDs) impair cortical experience-dependent plasticity (ExDP) similarly to stroke, finding no direct causal link between SDs/PiDs and metaplasticity changes.

This study investigates attentional alterations in migraine using behavioral and MEG/EEG data, finding increased bottom-up orienting responses and enhanced top-down attention recruitment in migraineurs.

This study investigates how melanopsin and cone signals contribute to photophobia in migraine and finds that migraineurs amplify ipRGC signals specifically for discomfort, not pupil responses.

This study investigates sex differences in post-traumatic headache-like behaviors and treatment responses in female rats after mild closed head injury, finding prolonged hyperalgesia and reduced effectiveness of anti-CGRP treatment in females.

The paper develops a mechanistic model of sodium transport across the blood-CSF and blood-brain barriers in rats to investigate their roles in migraine-associated sodium dysregulation.

The paper compares visual evoked potentials in migraineurs and controls to investigate cortical hyperexcitation and feedback mechanisms related to visual discomfort.

This study examines the relationship between neurochemical levels (GABA and Glx) in the occipital cortex and binocular rivalry percept duration in migraineurs and controls, finding no significant correlation.

This study shows that TRESK K+ channel activity is required for trigeminal pain regulation, with loss of TRESK increasing headache-like behaviors in mice.

This study shows that intact mast cells are required for latent pain sensitization after mild head injury, suggesting potential therapeutic targets for post-traumatic headache.

This study introduces Drosophila models with human migraine mutations in CaV2 channels, showing hyperexcitability that can be suppressed by inhibiting intracellular Ca2+ release.

This study shows that applied electric fields can modulate and prevent spreading depression in brain slices by altering its propagation path and speed.

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.

This study investigates the relationship between cortical spreading depression (CSD)-evoked metabolic changes and meningeal afferent activation in migraine, finding that metabolic perturbations are dissociated from afferent activation and sensitization.

This study identifies 28 genetic loci associated with broadly-defined headache using UK Biobank data, including 14 new loci and 14 previously linked to migraine.