Migraine and Headache Studies

This study shows that inhibiting PACAP-PAC1 receptors reduces opioid-induced chronic headache in mouse models by blocking PACAPergic mechanisms.

This paper develops an in vitro method to record and image spreading depolarizations and seizure-like events in mouse hippocampal slices without focal stimulation.

This study investigates sex differences in migraine prevalence using twin data, finding that genetic factors alone do not fully explain the sex difference, but prenatal hormone environments may contribute.

The paper examines functional connectivity changes across the migraine cycle, finding increased connectivity in the prodromal phase and its collapse during headache, suggesting a mechanism for normalizing cortical processing.

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

This study identifies a neocortex-specific mechanism of cortical spreading depression (CSD) initiated by hyperactivity of GABAergic neurons and NaV1.1 channel gain-of-function, linking it to Familial Hemiplegic Migraine type-3.

The paper assesses the role of ipRGCs and cones in reflexive eye closure as a measure of photophobia in migraine, finding enhanced responses in MwA compared to other groups.

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.

This study shows that inhibitory interneurons influence the initiation of cortical spreading depression by affecting pyramidal cell spike block through dynamic ion concentration changes.

The paper investigates gene expression changes during spontaneous migraine attacks and identifies differentially expressed genes and pathways associated with migraine pathophysiology.

This study shows HDAC6 inhibition restores neuronal complexity in chronic migraine models, suggesting it as a potential therapeutic target.

This study shows PACAP induces light aversion in mice independently of CGRP, with inheritable responder and nonresponder phenotypes and distinct gene expression patterns.

This study identifies Kcnq2/Kv7.2 as a gene modulating spreading depolarization threshold and bilateral symmetry, with implications for epilepsy and migraine.

This study investigates brain activity changes during migraine cycles, finding cyclic perfusion in the limbic circuit and hypothalamic connectivity shifts, suggesting the hypothalamus drives migraine attacks by losing control over the limbic system.

The paper identifies a direct trigeminal ganglion-to-parabrachial connection that processes dura inputs, suggesting a role in migraine pathogenesis.

The paper identifies non-canonical glutamate signaling in a migraine model, linking it to spreading depolarizations and potential therapeutic targets.

This study investigates whether spreading depolarizations (SDs) and periinfarct depolarizations (PiDs) impair cortical experience-dependent plasticity (ExDP) similarly to stroke, finding no direct causal link between SDs/PiDs and metaplasticity changes.

This study shows that acetate increases brainstem adenosine and glutamate, contributing to ethanol-induced headache via A2A receptor activation.

This study investigates attentional alterations in migraine using behavioral and MEG/EEG data, finding increased bottom-up orienting responses and enhanced top-down attention recruitment in migraineurs.

This study investigates how melanopsin and cone signals contribute to photophobia in migraine and finds that migraineurs amplify ipRGC signals specifically for discomfort, not pupil responses.

This study investigates the role of the meningeal lymphatic system in migraine pain by analyzing inflammatory and nociceptive responses in mice lacking this system.

This study measures GABA and glutamate levels in children with migraine using MRS, finding lower glutamate in the visual cortex and associations between metabolite levels and migraine characteristics.

This study investigates sex differences in post-traumatic headache-like behaviors and treatment responses in female rats after mild closed head injury, finding prolonged hyperalgesia and reduced effectiveness of anti-CGRP treatment in females.

The paper develops a mechanistic model of sodium transport across the blood-CSF and blood-brain barriers in rats to investigate their roles in migraine-associated sodium dysregulation.

The paper compares visual evoked potentials in migraineurs and controls to investigate cortical hyperexcitation and feedback mechanisms related to visual discomfort.

The paper maps cerebrovascular reactivity impairment in episodic migraineurs using fMRI and MRA, finding reduced BOLD responses in MOA patients at the red nucleus.

The paper develops a mathematical model showing mitochondrial calcium-phosphate dissolution drives prolonged vasoconstriction after cortical spreading depolarization.

This study examines the relationship between neurochemical levels (GABA and Glx) in the occipital cortex and binocular rivalry percept duration in migraineurs and controls, finding no significant correlation.

This study shows that TRESK K+ channel activity is required for trigeminal pain regulation, with loss of TRESK increasing headache-like behaviors in mice.

This study shows that intact mast cells are required for latent pain sensitization after mild head injury, suggesting potential therapeutic targets for post-traumatic headache.