Neurogenesis and neuroplasticity mechanisms

This study shows that depletion of the neuroepithelium stem cell pool determines the cessation of medulla NBs in Drosophila optic lobes, with multiple mechanisms contributing to their termination.

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

The paper shows that Barhl1 silences TCF activity to allow granule neuron progenitors to exit their niche in the upper rhombic lip.

The paper shows that abrogating filamin in mouse models of periventricular heterotopia increases neocortical neuron generation in the V-SVZ through oxidative metabolism and vascularization.

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

This paper quantitatively models the decline of adult neurogenesis in rodents across age, showing a significant reduction in new neurons' proportion in the hippocampus.

This study shows that oligodendrocyte dynamics after ischemia promote long-term remyelination and sensorimotor recovery in a rat model of stroke.

This study shows that synaptic vesicle release affects oligodendrocyte-axon interactions in a neuron subtype-specific manner in zebrafish.

This study shows that structural changes in neurons and adult neurogenesis in specific brain regions of house crows are linked to visual discrimination learning.

This study identifies Safb1 as a regulator of neuron production in adult hippocampal neural stem cells by enhancing Drosha-mediated cleavage of NFIB mRNA, preventing glial differentiation.

This study shows that oligodendrocytes regulate synchronized neural activity during development, affecting adult behavior through Purkinje cell synchrony.

The paper identifies the spatiotemporal expression patterns of Msx genes in the developing cerebellar neuroepithelium and shows their distinct localization in progenitor zones.

The paper explains the clonal composition of neural organoids using a neutral competition model that accounts for observed lineage size variability.

The paper shows that mitochondrial fusion during a critical period supports synaptic plasticity and circuit integration in adult-born neurons.

This paper shows that cerebellar folding follows a universal scaling law across species, despite clade-specific patterns, and relates this to physical principles of self-organization.

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.

This study uses three-photon imaging to show that white matter generates more oligodendrocytes than gray matter, but gray matter shows faster growth rates and regenerative deficits after injury.

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

This study identifies two classes of environmental chemicals that impair oligodendrocyte development through distinct mechanisms and links exposure to adverse neurodevelopmental outcomes.

The paper uses autofluorescence imaging to identify and track neural stem cell activation states in vitro and in vivo, linking it to transcriptional features and cell behavior.

This study shows that KIF7 deletion in mice disrupts cerebral cortex development by altering SHH signaling differently in dorsal and ventral forebrain regions, leading to structural and migratory defects in neurons.

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

This study identifies Prosaposin as a regulator of neural stem cell quiescence in zebrafish, showing it maintains deep quiescence and reduces activation.

This study identifies Mllt11's role in cerebellar granule cell migration and folia development, showing its impact on neuronal organization and cytoarchitecture.

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

This study shows that manipulating SLAP expression during brain development affects cortical lamination and exploratory behavior in mice.

This study evaluates the PenkCre mouse line as a tool to label and study embryonically-born dentate granule neurons in young mice.

The paper identifies importin 13b's role in axon diameter growth and shows its impact on conduction velocity in myelinated axons in zebrafish.