Gestational Diabetes Research and Management

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Identification of Heterogeneous Cortical Thickness Patterns Associated with Prenatal Gestational Diabetes Exposure: A SuStaIn-Based Subtyping Study

This study identifies two distinct cortical thickness subtypes in youth exposed to prenatal gestational diabetes, each associated with different neuroanatomical and clinical features.

Understanding Patient Perceptions of Genetic Testing to Predict Type 2 Diabetes Risk After Gestational Diabetes

This study assesses women's perceptions of genetic testing for predicting type 2 diabetes risk after gestational diabetes, finding high willingness and low data concerns, with demographic differences in acceptability and motivation.

Metabolic adaptation to maternal hyperglycemia via ACLY-dependent acetyl-CoA production drives epigenetic remodeling and dysregulated placental development

The paper identifies ACLY-dependent acetyl-CoA production as a mechanism linking maternal hyperglycemia to epigenetic remodeling and placental underdevelopment in gestational diabetes.

Differential activation of p53-Lamin A/C and p16-RB mediated senescence pathways in trophoblast from pregnancies complicated by type A2 Gestational Diabetes Mellitus

This study examines senescence pathways in trophoblasts from GDM pregnancies, finding sexually dimorphic dysregulation of p21, p16-RB, and p53-Lamin A/C pathways affecting trophoblast function.

Maternal DNA Methylation Signatures of Gestational Diabetes across all Stages of Pregnancy

This study identifies DNA methylation signatures associated with gestational diabetes mellitus across pregnancy stages and discovers new genes potentially linked to GDM and related diseases.

Examining the impact of gestational diabetes genetic susceptibility variants on maternal glucose levels during and post-pregnancy

This study examines how genetic variants linked to gestational diabetes affect maternal glucose levels during and after pregnancy, finding consistent associations with fasting glucose but varying effects on postprandial glucose.

Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes

The paper examines how maternal obesity and gestational diabetes affect placental mitochondrial structure, dynamics, and clearance, finding sex-specific differences in mitochondrial function and quality control.

Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus

This study investigates the genetic associations of early pregnancy C-reactive protein (CRP) levels with gestational diabetes mellitus (GDM) using maternal and offspring genome-wide association studies (GWAS).

Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism

The paper examines lipidomic changes in maternal blood and placental tissue in obesity and gestational diabetes, revealing sexually dimorphic effects in placental fatty acid composition.

Suppression of PCBP1 Enhances PPARgamma via TAK1 Modulation to Improve Glycemic and Lipid Metabolism Disorders in Gestational Diabetes Mellitus

This study shows that suppressing PCBP1 improves glycemic and lipid metabolism in GDM by modulating TAK1 and PPARgamma signaling.

Genetic studies of gestational diabetes mellitus in 21,813 Chinese women

This study identifies four genome-wide significant SNPs associated with GDM in Chinese women and develops an early prediction model using clinical and genetic indicators.

Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits

This study identifies four genetic loci associated with gestational diabetes risk and 31 loci linked to glycaemic traits in 30,699 Chinese pregnant women, with MTNR1B showing the strongest association.

The impact of hyperglycemia upon BeWo trophoblast cell metabolic function: A multi-OMICS and functional metabolic analysis

This study investigates how hyperglycemia affects placental trophoblast cell metabolism and nutrient storage using BeWo cells, finding increased glycogen and triglyceride stores but no changes in mitochondrial function.

The Genetic Risk of Gestational Diabetes in South Asian women

This study finds that a type 2 diabetes polygenic risk score is strongly associated with gestational diabetes-related traits in South Asian women, accounting for a significant portion of the population attributable fraction.

Identification of differentially expressed genes and signaling pathways in gestational diabetes mellitus by integrated bioinformatics analysis

Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus

This study identifies key biomarkers and potential drug candidates for gestational diabetes mellitus through transcriptomic analysis and molecular docking.

All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes

The paper examines how different glucose thresholds for gestational diabetes identify women with higher genetic risk for type 2 diabetes using genetic scores.

Genome-Wide Polygenic Risk Scores and prediction of Gestational Diabetes in South Asian Women

This study develops polygenic risk scores for gestational diabetes in South Asian women using multi-ethnic summary statistics and validates them in UK Biobank data, finding moderate heritability.

Genetic association between angiotensin converting enzyme gene in Saudi obese women established gestational diabetes; Non-replication of case-control studies in insertion and deletion polymorphism

The paper investigates the association between ACE polymorphism and gestational diabetes mellitus in Saudi women, finding a positive link with certain genotypes but no replication in obese subgroups.

Maternal and fetal genetic contribution to gestational weight gain

This study investigates the genetic contributions to gestational weight gain, finding that maternal common variants explain about 20% of variability, while fetal variants have a minor role.